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With the development of the NAND-Flash technology, NAND-Flash based Solid-State Disk (SSD) has been attracting a great deal of attention from both industry and academia. While a range of SSD research topics, from interface techniques to buffer management and Flash Translation Layer (FTL), from performance to endurance and energy efficiency, have been(More)
The combination of high-density transposon-mediated mutagenesis and high-throughput sequencing has led to significant advancements in research on essential genes, resulting in a dramatic increase in the number of identified prokaryotic essential genes under diverse conditions and a revised essential-gene concept that includes all essential genomic elements,(More)
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic(More)
Given the multilevel internal SSD parallelism at the different four levels: channel-level, chip-level, die-level, and plane-level, how to exploit these levels of parallelism will directly and significantly impact the performance and endurance of SSDs, which is in turn primarily determined by three internal factors, namely, advanced commands, allocation(More)
Replication of chromosomes is one of the central events in the cell cycle. Chromosome replication begins at specific sites, called origins of replication (oriCs), for all three domains of life. However, the origins of replication still remain unknown in a considerably large number of bacterial and archaeal genomes completely sequenced so far. The(More)
Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation, acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key role in the regulation of diverse cellular physiology. Here we report discovery of a new type of lysine PTM, lysine malonylation (Kmal). Kmal was initially detected by mass(More)
Recommender systems always aim to provide recommendations for a user based on historical ratings collected from a single domain (e.g., movies or books) only, which may suffer from the data sparsity problem. Recently, several recommendation models have been proposed to transfer knowledge by pooling together the rating data from multiple domains to alleviate(More)
BACKGROUND The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia. Chronic inflammatory nociception of rats was produced by intraplantar injection of complete Freund's adjuvant (CFA) and data was collected(More)
In tonal languages such as Mandarin Chinese, a lexical tone carries semantic information and is preferentially processed in the left brain hemisphere of native speakers as revealed by the functional MRI or positron emission tomography studies, which likely measure the temporally aggregated neural events including those at an attentive stage of auditory(More)