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Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growth factor 1 (IGF-I) signalling. Using DNA microarray analysis, we have found that DAF-16 affects expression of a set of genes during early adulthood, the time at(More)
This paper presents a system for performance-based character animation that enables any user to control the facial expressions of a digital avatar in realtime. The user is recorded in a natural environment using a non-intrusive, commercially available 3D sensor. The simplicity of this acquisition device comes at the cost of high noise levels in the acquired(More)
We present a framework and algorithms for robust geometry and motion reconstruction of complex deforming shapes. Our method makes use of a smooth template that provides a crude approximation of the scanned object and serves as a geometric and topological prior for reconstruction. Large-scale motion of the acquired object is recovered using a novel(More)
We developed a method for systematically comparing gene expression patterns across organisms using genome-wide comparative analysis of DNA microarray experiments. We identified analogous gene expression programs comprising shared patterns of regulation across orthologous genes. Biological features of these patterns could be identified as highly conserved(More)
We present a registration algorithm for pairs of deforming and partial range scans that addresses the challenges of non-rigid registration within a single non-linear optimization. Our algorithm simultaneously solves for correspondences between points on source and target scans, confidence weights that measure the reliability of each correspondence and(More)
Convolutional Neural Networks (CNNs) are extensively used in image and video recognition, natural language processing and other machine learning applications. The success of CNNs in these areas corresponds with a significant increase in the number of parameters and computation costs. Recent approaches towards reducing these overheads involve pruning and(More)
It is widely suspected that gene regulatory networks are highly plastic. The rapid turnover of transcription factor binding sites has been predicted on theoretical grounds and has been experimentally demonstrated in closely related species. We combined experimental approaches with comparative genomics to focus on the role of combinatorial control in the(More)
Removal of rain streaks in video is a challenging problem due to the random spatial distribution and fast motion of rain. This paper presents a new rain removal algorithm that incorporates both temporal and chromatic properties of rain in video. The temporal property states that an image pixel is never always covered by rain throughout the entire video. The(More)
In this paper, we introduce the second version of Microsoft Research Asia Multimedia (MSRA-MM), a dataset that aims to facilitate research in multimedia information retrieval and related areas. The images and videos in the dataset are collected from a commercial search engine with more than 1000 queries. It contains about 1 million images and 20,000 videos.(More)
The glucocorticoid receptor (GR) associates with glucocorticoid response elements (GREs) and regulates selective gene transcription in a cell-specific manner. Native GREs are typically thought to be composite elements that recruit GR as well as other regulatory factors into functional complexes. We assessed whether GR occupancy is commonly a limiting(More)