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Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growth factor 1 (IGF-I) signalling. Using DNA microarray analysis, we have found that DAF-16 affects expression of a set of genes during early adulthood, the time at(More)
This paper presents a system for performance-based character animation that enables any user to control the facial expressions of a digital avatar in realtime. The user is recorded in a natural environment using a non-intrusive, commercially available 3D sensor. The simplicity of this acquisition device comes at the cost of high noise levels in the acquired(More)
We developed a method for systematically comparing gene expression patterns across organisms using genome-wide comparative analysis of DNA microarray experiments. We identified analogous gene expression programs comprising shared patterns of regulation across orthologous genes. Biological features of these patterns could be identified as highly conserved(More)
Convolutional Neural Networks (CNNs) are extensively used in image and video recognition, natural language processing and other machine learning applications. The success of CNNs in these areas corresponds with a significant increase in the number of parameters and computation costs. Recent approaches towards reducing these overheads involve pruning and(More)
OBJECTIVE To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs. DESIGN Case-control study with replication. SETTING Memory referral clinics in Canada and the United Kingdom. PARTICIPANTS The hypothesis-generating data set consisted of 753(More)
In this paper, we introduce the second version of Microsoft Research Asia Multimedia (MSRA-MM), a dataset that aims to facilitate research in multimedia information retrieval and related areas. The images and videos in the dataset are collected from a commercial search engine with more than 1000 queries. It contains about 1 million images and 20,000 videos.(More)
In a statistical approach to protein structure analysis, Miyazawa and Jernigan (MJ) derived a 20 × 20 matrix of inter-residue contact energies between different types of amino acids. Using the method of eigenvalue decomposition, we find that the MJ matrix can be accurately reconstructed from its first two principal component vectors as Mij = C0 + C1(qi +(More)
We present a registration algorithm for pairs of deforming and partial range scans that addresses the challenges of non-rigid registration within a single non-linear optimization. Our algorithm simultaneously solves for correspondences between points on source and target scans, confidence weights that measure the reliability of each correspondence and(More)
The CRISPR/Cas9 system is becoming an important genome editing tool for crop breeding. Although it has been demonstrated that target mutations can be transmitted to the next generation, their inheritance pattern has not yet been fully elucidated. Here, we describe the CRISPR/Cas9-mediated genome editing of four different rice genes with the help of online(More)
Removal of rain streaks in video is a challenging problem due to the random spatial distribution and fast motion of rain. This paper presents a new rain removal algorithm that incorporates both temporal and chromatic properties of rain in video. The temporal property states that an image pixel is never always covered by rain throughout the entire video. The(More)