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BACKGROUND No single standard treatment exists for patients with small, node-negative, human epidermal growth factor receptor type 2 (HER2)-positive breast cancers, because most of these patients have been ineligible for the pivotal trials of adjuvant trastuzumab. METHODS We performed an uncontrolled, single-group, multicenter, investigator-initiated(More)
Worms can spread throughout the Internet very quickly and are a great security threat. Constant quarantine strategy is a defensive measure against worms, but its reliability in current imperfect intrusion detection systems is poor. A pulse quarantine strategy is thus proposed in the current study. The pulse quarantine strategy adopts a hybrid intrusion(More)
Resting state functional brain networks have been widely studied in brain disease research. However, it is currently unclear whether abnormal resting state functional brain network metrics can be used with machine learning for the classification of brain diseases. Resting state functional brain networks were constructed for 28 healthy controls and 38 major(More)
Image inpainting provides a means to restore damaged region of an image, such that the image looks complete and natural after the inpainting process. This paper presents a new inpainting algorithm, which implements the filling of damaged region based on morphological erosion and structure feature replication. The method, which is based on a(More)
Curcumin is a major constituent of curcuma longa, a traditional medicine used to manage mental disorders effectively in China. The neuroprotective effects of curcumin have been demonstrated in our previous studies. In the present research, we confirmed this effect by showing that curcumin application promoted the viability of cultured rodent cortical(More)
OBJECTIVE Diabetic encephalopathy is characterised by cognitive impairment, neurochemical and structural abnormalities. The aim of the study was to investigate the effects of ibuprofen on diabetic encephalopathy and potential mechanisms. RESEARCH DESIGN AND METHOD Diabetes was induced through a single intraperitoneal injection of streptozotocin (60(More)
GSK3β genotypes may interact with major depressive disorder (MDD) and may have a role in determining regional gray matter volume differences from healthy comparison subjects. However, any associations of GSK3β genotypes with MDD related to abnormal functional brain activity have yet to be elucidated. In the present study, resting state functional brain(More)