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The gut microbiota as an environmental factor that regulates fat storage.
- F. Bäckhed, Hao Ding, J. Gordon
- BiologyProceedings of the National Academy of Sciences…
- 2 November 2004
It is found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
This work identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people by targeted sequencing, contributing to the understanding of the disease mechanism ofNKTCL.
XPD suppresses cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC
It is found that the expression of XPD and miR-29a-3p was downregulated in HCC samples and HCC cell lines and indicated that XPD suppressed cell proliferation and migration via miR+3p-Mdm2/PDGF-B axis in H CC.
LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression
The underlying mechanism for tumour oncogenesis of ANCR in HCC metastasis is investigated and it is found that ANCR promoted the EMT and invasion/migration of HCC cells through regulating HNRNPA1.
Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: A meta-analysis.
CCND1 silencing suppresses liver cancer stem cell differentiation and overcomes 5-Fluorouracil resistance in hepatocellular carcinoma.
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons
This study demonstrates that peripheral nerve injury–induced downregulation of ZNF382 in DRG contributes to neuropathic pain likely through silencer-based epigenetic disinhibition of CXCL13, a key…
Prussian blue nanoparticle-labeled aptasensing platform on graphene oxide for voltammetric detection of α-fetoprotein in hepatocellular carcinoma with target recycling.
An enzyme-free electrochemical aptasensing platform based on a graphene oxide nanosheet-modified gold-disk electrode was developed for the voltammetric detection of alpha-fetoprotein (AFP) in hepatocellular carcinoma by using a Prussian blue nanoparticle (PBNP)-labeled aptamer, and provides a new horizon for the determination of disease-related proteins.
Inositol-Requiring Kinase 1 Regulates Apoptosis via Inducing Endoplasmic Reticulum Stress in Colitis Epithelial Cells
The role of inositol-requiring kinase 1 (IRE-1), a major regulator of ER, in regulating ERS and cell viability was analyzed and inhibition of IRE-1 enhanced unfolded protein response and cells apoptosis and IL-6-induced ERS was demonstrated.