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The gut microbiota as an environmental factor that regulates fat storage.
It is found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake. Expand
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
This work identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people by targeted sequencing, contributing to the understanding of the disease mechanism ofNKTCL. Expand
Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: A meta-analysis.
Both PAC and PAM regimens were effective and comparable in eradicating H. pylori, however, the PAM regimen showed greater efficacy than the PAC regimen in recent years, especially for people over 60 years old. Expand
XPD suppresses cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC
It is found that the expression of XPD and miR-29a-3p was downregulated in HCC samples and HCC cell lines and indicated that XPD suppressed cell proliferation and migration via miR+3p-Mdm2/PDGF-B axis in H CC. Expand
Prussian blue nanoparticle-labeled aptasensing platform on graphene oxide for voltammetric detection of α-fetoprotein in hepatocellular carcinoma with target recycling.
An enzyme-free electrochemical aptasensing platform based on a graphene oxide nanosheet-modified gold-disk electrode was developed for the voltammetric detection of alpha-fetoprotein (AFP) in hepatocellular carcinoma by using a Prussian blue nanoparticle (PBNP)-labeled aptamer, and provides a new horizon for the determination of disease-related proteins. Expand
LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression
The underlying mechanism for tumour oncogenesis of ANCR in HCC metastasis is investigated and it is found that ANCR promoted the EMT and invasion/migration of HCC cells through regulating HNRNPA1. Expand
XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway.
XPD could suppress growth of hepatoma cells, up-regulate the expressions of P21 and Bax, and down- Regulate the expression of Bcl-2 and HBx through the P53 pathway, and there may be mutual influences among XPD, P53 andHBx that co-regulates hepatocarcinogenesis. Expand
CCND1 silencing suppresses liver cancer stem cell differentiation and overcomes 5-Fluorouracil resistance in hepatocellular carcinoma.
Collectively, CCND1 silencing suppresses LCSCs differentiation and overcomes 5-Fu resistance in HCC. Expand
Silencing of Xeroderma Pigmentosum Group D Gene Promotes Hepatoma Cell Growth by Reducing P53 Expression
XPD silencing promoted growth of hepatoma cells by reducing P53 expression and promoting cell proliferation, reduced apoptosis, and promoted cell invasive ability. Expand
Overexpression of C-sis inhibits H2O2-induced Buffalo rat liver cell apoptosis in vitro and alleviates liver injury in a rat model of fulminant hepatic failure
  • Hao Ding, Zhi-Li Wen
  • Chemistry, Medicine
  • International journal of molecular medicine
  • 17 May 2018
The overexpression of C-sis inhibited the H2O2-induced apoptosis of BRL cells in vitro, and alleviated liver injury, improved liver function, and decreased mortality rates in rat models of FHF. Expand