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Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
TLDR
Results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors, and are activated by various acids when coexpressed in heterologous cells but not by other classes of tastants. Expand
Genetic variation in a human odorant receptor alters odour perception
TLDR
It is shown that a human odorant receptor, OR7D4, is selectively activated in vitro by androstenone and the related odorous steroid androstadienone and does not respond to a panel of 64 other odours and two solvents. Expand
Odor Coding by a Mammalian Receptor Repertoire
TLDR
The results provide a basis for translating odorants into receptor neuron responses and for unraveling mammalian odor coding, and a model for predicting interactions between ORs and their ligands is developed. Expand
Synergism of Accessory Factors in Functional Expression of Mammalian Odorant Receptors*
TLDR
It is shown that a shorter form of RTP 1, RTP1S, supports robust cell-surface and functional expression of representative odorant receptors, and the presence or absence of different N-terminal tags has little effect on the ligand specificity of odorant antagonists, although the amount of receptor expressed can play a role in the lig and response profile. Expand
Odor coding by a mammalian receptor repertoire
TLDR
Depletion of orexin may contribute to the adverse effect of ropinirole such as sleep attacks and daytime sleepiness during the treatment of Parkinson disease. Expand
The Missense of Smell: Functional Variability in the Human Odorant Receptor Repertoire
TLDR
To show that in vitro results are relevant to olfactory perception, it is verified that variations in OR10G4 genotype explain over 15% of the observed variation in perceived intensity and over 10% in perceived valence for the high-affinity in vitro agonist guaiacol but do not explain phenotype variation for the lower-Affinity agonists vanillin and ethyl vanillin. Expand
Implausibility of the vibrational theory of olfaction
TLDR
The vibrational theory of olfaction posits detection of odorants through their vibrational frequencies rather than solely through “hand-in-glove” substrate/enzyme-like odorant–odorant receptor (OR) interactions, but there is no evidence for differentiation at the molecular level. Expand
Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells
TLDR
This protocol details the method used for evaluating the cell-surface expression and measuring the functional activation of ORs of transiently expressed mammalian ORs in HEK293T cells. Expand
Reply to Turin et al.: Vibrational theory of olfaction is implausible
TLDR
The reported results were directed at testing the main hypothesis of the vibrational theory of olfaction, which has never been supported by experimental data at the receptor level, providing clear experimental evidence against the vibration mechanistic hypothesis in a biological milieu. Expand
BitterX: a tool for understanding bitter taste in humans
TLDR
BitterX may be an effective method for deciphering bitter taste coding and could be a useful tool for both basic bitter research in academia and new bitterant discoveries in the industry. Expand
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