Hansruedi Zwicker

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Androstanediol glucuronide (Adiol G) has been reported to be a marker of peripheral androgen metabolism and action. It consists of two isomers, Adiol 3-G and Adiol 17-G. Adiol G is formed from unconjugated precursors by the enzyme glucuronyl transferase. To determine the likely source of Adiol G formation in man, we developed a glucuronyl transferase assay(More)
Testosterone exerts negative feedback control on gonadotropin secretion either directly, after aromatization to estradiol, or after 5 alpha-reduction to dihydrotestosterone (DHT). Conflicting data exist as to the role of DHT in the modulation of this negative feedback. To determine whether suppression of endogenous DHT alters gonadotropin secretion, we gave(More)
Medical treatment of Graves' disease involves use of antithyroid drugs with or without the addition of exogenous L-T4. There have been conflicting reports as to whether the addition of T4 reduces TSH receptor antibodies and improves remission rates more than antithyroid drugs alone. To further examine the effect of drug therapy on serum concentrations of(More)
The red blood cell eluates of two patients with warm autoimmune hemolytic anemia (AIHA) were found to have anti-dl and anti-Wrb in a study of 150 individuals with positive AHG tests.7 In that series 39 per cent of AIHA cases had anti-Wrb as part of the autoantibody specificity. The eluates of these two patients were of further interest since they showed(More)
The clinical picture of cystic degeneration of the adventitia is illustrated by two cases. This usually occurs in a portion of an artery near a joint, most commonly in the popliteal artery. The diagnosis is made in the presence of irregular, intermittent claudication associated with an "hour glass" stenosis of the popliteal artery on the arteriogram,(More)
The article reports on two female patients with cancer of the breast who had primarily not been treated by surgery or exposure to radiation, but only with cytostatics. Complete remission of the tumour occurred in both patients in the course of several years of treatment. These two examples show that in patients with cancer of the breast in stages which(More)