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The aim of this article is to introduce the robotic orthosis Lokomat, developed to automate treadmill training rehabilitation of locomotion for spinal cord injured and stroke patients, to the Functional Electrical Stimulation (FES) and Neuromodulation research communities, and to report on our newly conducted research. We first illustrate the primary use of(More)
The conclusions concerning hemispheric specializations based on neural network simulations, which were previously reported by Kosslyn, Chabris, Marsolek, and Koenig (1992), are shown not to be valid. Differences in network performance on tasks said to be "categorical" and "coordinate spatial" in nature were due to imbalances in the input stimuli and cannot,(More)
The N-acetylglutamate deacetylase (EC 3.5.1.-) from Pseudomonas aeruginosa, strain PAO1, was purified 15,000-fold to electrophoretic homogeneity. The enzyme was distinct from acetylornithinase and formylglutamate hydrolase. Its molecular weight was estimated to be 90,000 by gel filtration and by sedimentation in sucrose gradients. Electrophoresis in(More)
Human myeloblastin (leukocyte proteinase 3) shares many biochemical properties with leukocyte elastase, but rapidly loses enzymatic activity when raising the pH and/or the ionic strength of an acidic solution or when handled in glass vessels. This poses limits to kinetic experiments requiring long incubation times. After purification, myeloblastin was(More)
Human myeloblastin (leucocyte proteinase 3) showed a very slow approach to the steady-state velocity when the pH was rapidly increased from 3.2 to 7.0. The kinetic mechanism of this hysteretic process was interpreted as a slow conformational change of myeloblastin from an inactive form at acidic pH to the active form at neutral pH. The transition between(More)
Prepulse inhibition (PPI) is the normal suppression of the startle reflex when an intense stimulus is preceded by a weak non-startling prestimulus. PPI is widely used as a model for sensorimotor gating processes and has been shown to be impaired in various neuropsychiatric disorders, including schizophrenia. We have reproduced startle-like behavior and(More)
A survey of mental rotation strategies in 210 normal subjects showed a strong tendency for right-handers to prefer rotating an object on the right and vice versa for left-handers. The differential functioning of the cerebral hemispheres during mental rotation was then assessed in 42 subjects by means of tachistoscopic presentation of two geometrical figures(More)
D1 dopamine receptor mRNA has been demonstrated in mouse melanoma cells, and the expression of these G-protein-coupled receptors in human melanoma was therefore presumed when dopamine receptor binding radiopharmaceuticals were found to be useful for the detection of metastases in whole-body scintigraphy. The aim of this study was thus to investigate if D1(More)
  • H Früh
  • 1983
The efficacy of a new topic preparation of the corticosteroid Halcinonide containing 5% Urea has been examined and then compared with two commercial preparations of Halcinonide and Betamethasonevalerate respectively. Although these two corticosteroids usually do not belong to the same class of potency, there could not be found any significant difference(More)