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As the complexity of digital filters is dominated by the number of multiplications, many works have focused on minimizing the complexity of multiplier blocks that compute the constant coefficient multiplications required in filters. Although the complexity of multiplier blocks is significantly reduced by using efficient techniques such as decomposing(More)
Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra. There is a need for genetic animal models of PD for screening and in vivo testing of novel restorative therapeutic agents. Although current genetic models of PD produce behavioral impairment and nigrostriatal dysfunction, they do(More)
—To improve memory bandwidth and power consumption in video applications, a new memory-interface architecture is proposed. The architecture adopts an array address-translation technique to utilize the fact that video-processing algorithms have regular memory-access patterns. Since the translation can minimize the number of overhead cycles needed for(More)
Midbrain dopamine (mDA) neurons play critical roles in the regulation of voluntary movement and their dysfunction is associated with Parkinson's disease. Pitx3 has been implicated in the proper development of mDA neurons in the substantia nigra pars compacta, which are selectively lost in Parkinson's disease. However, the basic mechanisms underlying its(More)
The Hybrid Signed Digit (HSD) representation introduced in [9] employs both signed and unsigned digits and renders the maximum length of carry propagation equal to the maximum distance between two consecutive signed digits. This representation offers a continuum of choices from two's complement representation on one extreme (where there are no signed(More)
BACKGROUND Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy promoter methylation was previously identified as a basis for the complete silencing of RFC in MDA-MB-231 breast cancer cells, its role and(More)
Semiconductor fabs are capital intensive. The rate of capital return heavily depends on their productivity. Accordingly, simulation has been adopted in many cases as a viable design and analysis tool to achieve better productivity. However, the gap between the simplistic simulation models and real complex systems has limited the confidence to apply(More)