Learn More
We present a programmable droplet-based microfluidic device that combines the reconfigurable flow-routing capabilities of integrated microvalve technology with the sample compartmentalization and dispersion-free transport that is inherent to droplets. The device allows for the execution of user-defined multistep reaction protocols in 95 individually(More)
Single-cell genomics is critical for understanding cellular heterogeneity in cancer, but existing library preparation methods are expensive, require sample preamplification and introduce coverage bias. Here we describe direct library preparation (DLP), a robust, scalable, and high-fidelity method that uses nanoliter-volume transposition reactions for(More)
Obiective of study: Synthesis and characterization of new bismuth complexes with antitumor activity. Method used: Characterization of the new compounds by elemental analyses, conductivity measurements, spectroscopical methods OR, ~H-N/vlR, ~3C-NMR) and single-crystal X-ray structure analyses of some representative compounds. Tests of antitumor activity in(More)
We report the development and application of a microfluidic random access memory (RAM) that enables fully programmable formulation of an array of 95 nanolitre-scale reactions and subsequent random access to any reaction for addition of reagents or selective extraction of reaction products. This functionality is enabled by a novel droplet docking mechanism(More)
Heterogeneity in the clonal outputs of individual human embryonic stem cells (hESCs) confounds analysis of their properties in studies of bulk populations and how to manipulate them for clinical applications. To circumvent this problem we developed a microfluidic device that supports the robust generation of colonies derived from single ESCs. This(More)
  • 1