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We performed a multicenter, double-blind, randomized study to evaluate the effect of diltiazem on reinfarction after a non-Q-wave myocardial infarction. Nine centers enrolled 576 patients: 287 received diltiazem (90 mg every six hours) and 289 received placebo. Treatment was initiated 24 to 72 hours after the onset of infarction and continued for up to 14(More)
This study evaluates the possible role of the mitral apparatus in left ventricular function after correction of chronic mitral regurgitation. Seventeen patients underwent complete preoperative and early postoperative heart catheterization. Six patients underwent conventional mitral valve replacement (group 1), six mitral valve replacement with preservation(More)
The initial 102 patients who underwent aorta-coronary bypass grafting between 1969 and 1971 were followed for a mean of 96 months (minimum follow-up 7 years). Preoperative variables predictive of survival at 5 years were stability of angina, previous heart failure, and left ventricular function. Stability of angina, previous heart failure, previous(More)
To examine the prevalence, clinical significance, and problems in the diagnosis of myocardial infarct (MI) extension, 103 patients with acute MI were studied. Each patient underwent enzymatic infarct sizing in the initial 72 hours and then had quantitative CK-MB (myocardial isoenzyme of serum creatine kinase) analysis at 8-hour intervals over the remaining(More)
Glyceryl trinitrate was previously said to be contraindicated in patients with acute myocardial infarction. Its intravenous administration during acute infarction, however, was associated with a beneficial effect as determined by ST segment mapping. Most recently in a selected group of patients with acute infarction and abnormal haemodynamics, intravenous(More)
A total of 89 patients, age 80 years or older at the time of initial permanent pacemaker implantation, were followed for 10 to 128 months [mean 32.7]. There were 54 males and 35 females. The mean age was 84.8 years. There were 51 patients age 80-84, 25 age 85-89, and 13 age 90-94. The actuarial 5-year survival was 45%. Complications occurred in 23 patients(More)
A 55-year-old man with acute inferior myocardial infarction was shown to have right ventricular involvement based on elevated jugular venous pressure, prominent A waves, and Kussmaul's sign. The ECG showed ST segment elevation in V3R with evolution of Q waves in the inferior leads. Technetium pyrophosphate images showed focal uptake in the inferior region(More)