Hans-Peter Vosberg

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Noncompaction of the ventricular myocardium (NVM) is the morphological hallmark of a rare familial or sporadic unclassified heart disease of heterogeneous origin. NVM results presumably from a congenital developmental error and has been traced back to single point mutations in various genes. The objective of this study was to determine the underlying(More)
DISSERTATION Genetic analysis in hypertrophic cardiomyopathy: missense mutations in the ventricular myosin regulatory light chain gene zur Erlangung des akademischen Grades Doctor medicinae (Dr. med.) Abstract Hypertrophic cardiomyopathy (HCM) is a heart disorder characterized by unexplained ventricular myocardial hypertrophy and a high risk of sudden(More)
Hypertrophic cardiomyopathy (HCM) is a dominant genetic disorder of the myocardium associated with dysfunctional contractile proteins. The major risk of HCM is sudden cardiac death, which may occur even in asymptomatic carriers. Causes are highly heterogeneous. Over 140 different mutations in nine sarcomeric genes have been described to date. The majority(More)
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