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OBJECTIVE Development of a rational and enforceable basis for controlling the impact of cannabis use on traffic safety. METHODS An international working group of experts on issues related to drug use and traffic safety evaluated evidence from experimental and epidemiological research and discussed potential approaches to developing per se limits for(More)
RATIONALE Carbamazepine (CBZ) is known to produce cognitive side effects being at least partly relevant for driving. In contrast to this, the cognitive effects of oxcarbazepine (OXC) are suspected to be less pronounced. OBJECTIVE This study aimed to test 900 mg/day OXC as compared to 600 mg/day CBZ with respect to driving. METHODS Driving performance of(More)
Comparing drug-induced driving impairments with the effects of benchmark blood alcohol concentrations (BACs) is an approved approach to determine the clinical relevance of findings for traffic safety. The present study aimed to collect alcohol calibration data to validate findings of clinical trials that were derived from a representative test course in a(More)
ADAS have the potential to optimize safety and efficiency in road traffic. In order to reach this objective, human-centered design principles have to be considered. Therefore, the effects of such devices on driver behavior and emotion are often analyzed quantitatively by using driving simulator studies that measure effects on individual level. But(More)
For the various demands of the experiments carried out in the IZVW driving simulator a new concept for databases was developed. The road network and the surrounding features of landscape and terrain, flora and buildings are represented in a topological way. Through this the geometrical representation is computed during the simulation in a small area(More)
In databases based on the architecture developed at the IZVW, the road network can be changed during simulation. Changes can be made depending on drivers' behaviour, drivers' state, or triggered by the supervisor of an experiment. We present two improvements of this architecture. The first deals with automatic generation of landscapes surrounding the roads.(More)
Currently, it is unclear whether sleep attacks in Parkinson's disease (PD) represent a novel entity or just a phenomenon of daytime sleepiness. We investigated 10 PD patients with sleep attacks and compared them with 10 PD patients without any daytime sleepiness. The patients were matched according to their dopaminergic medication and subjected to a sleep(More)