Hans M M Groenewoud

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Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, ≈5-minute ischemia) and method of analysis(More)
BACKGROUND Pain Exposure Physical Therapy is a new treatment option for patients with Complex Regional Pain Syndrome type 1. It has been evaluated in retrospective as well as in prospective studies and proven to be safe and possibly effective. This indicates that Pain Exposure Physical Therapy is now ready for clinical evaluation. The results of an earlier(More)
Finnish investigators [Vartiainen et al. Environmental Chemicals and Changes in Sex Ratio: Analysis Over 250 Years in Finland. Environ Health Perspect 107:813-815 (1999)] presented the sex ratio of all newborn babies from 1751 to 1997 in order to evaluate whether Finnish long-term data are compatible with the hypothesis that the decrease in the ratio of(More)
OBJECTIVES Among runners the reported prevalence of exercise-induced gastrointestinal (GI) symptoms is high (25%-83%). We aimed to investigate the prevalence of GI symptoms in women during a 5-10 km run in general and to explore the association between nutritional intakes and GI symptoms. SETTING As part of the Marikenloop-study (a cohort study to(More)
OBJECTIVE To compare the effectiveness of pain exposure physical therapy (PEPT) with conventional treatment in patients with complex regional pain syndrome type 1 (CRPS-1) in a randomised controlled trial with a blinded assessor. SETTING The study was conducted at a level 1 trauma centre in the Netherlands. PARTICIPANTS 56 adult patients with CRPS-1(More)
To determine the associations of fecundity and childlessness with month of conception and to find a causal mechanism for these associations, we reanalyzed some of our previous data according to the predictions of the seasonal optimal ripening oocyte (SOptRO) and seasonal preovulatory over-ripeness ovopathy (SPrOO) hypotheses. Prime and minor SOptRO months(More)
OBJECTIVE The Neck Disability Index (NDI) is a patient self-assessed outcome measurement tool to assess disability, and that is frequently used to evaluate the effects of the treatment of neck-related problems. In individualized medicine it is mandatory that patients can interpret data in order to choose a treatment. A change of NDI or an absolute NDI is(More)
In a continuation of a prospective longitudinal cohort study in a healthy population on the course of skull shape from birth to 24 months, at 5 years of age, 248 children participated in a follow-up assessment using plagiocephalometry (ODDI-oblique diameter difference index, CPI-cranio proportional index). Data from the original study sampled at birth, 7(More)
BACKGROUND To obtain evidence for the clinical and cost-effectiveness of treatments for patients with rare diseases is a challenge. Non-dystrophic myotonia (NDM) is a group of inherited, rare muscle diseases characterized by muscle stiffness. The reimbursement of mexiletine, the expert opinion drug for NDM, has been discontinued in some countries due to a(More)
BACKGROUND Cervical spondylotic myelopathy (CSM) is often encountered in daily practice. In this randomized controlled trial, laminectomy without fusion is compared with laminectomy followed by fusion. METHODS Patients with clinical signs and symptoms of CSM were included. At regular follow-up moments a Modified Japanese Orthopedic Association (mJOA)(More)