Hans-Joachim Eisele

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OBJECTIVES To investigate whether NADPH oxidase 2 (NOX2), a major source of reactive oxygen species (ROS), contributes to the emergence of arterial hypertension in a murine model of sleep apnea. BACKGROUND Obstructive sleep apnea (OSA) is a risk factor for arterial hypertension and it is linked to oxidative stress. METHODS C57BL/6J mice were exposed to(More)
Obstructive sleep apnea (OSA) is a frequent disease mainly affecting obese people and caused by repetitive collapse of the upper airways during sleep. The increased morbidity and mortality of OSA are mainly thought to be the consequence of its adverse effects on cardiovascular (CV) health. In this context, oxidative stress induced by nocturnal intermittent(More)
Melkersson–Rosenthal syndrome (MRS) is a rare disorder of unknown etiology. It is characterized by the triad of macrocheilitis, peripheral facial palsy, and lingua plicata. A 48-year-old nonobese man with a diagnosis of MRS and marked macroglossia was evaluated because of clinically suspected obstructive sleep apnea (OSA). Established causes of OSA such as(More)
The clinical spectrum of obstructive sleep apnea-(OSA-)related cardiovascular disease (CVD) comprises systemic arterial hypertension (prevalence: 40-60%), pulmonary hypertension (20-30%), coronary artery disease (20-30%), congestive heart failure (5-10%), and stroke (5-10%). During sleep, heart rhythm disorders such as atrioventricular blocks, sinus arrests(More)
Die vaskulären Folgeerkrankungen der obstruktiven Schlafapnoe (OSA) umfassen die systemarterielle Hypertonie (Prävalenz: 40–60%), die pulmonalarterielle Hypertonie (20–30%), die koronare Herzerkrankung (20–30%), die Linksherzinsuffizienz (5–10%) sowie Schlaganfälle (5–10%). Während der Nacht können durch die OSA verschiedene Herzrhythmusstörungen induziert(More)
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