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The retinal periphery of nine healthy subjects was stimulated with computer-generated random-dot kinematograms. These stimuli provided almost isolated visual motion information and minimal position cues. Pattern-reversal stimuli at the same location in the visual field were used for control. Stimulus-related electrical brain activity was recorded from 29(More)
Bereitschaftspotentials (BPs) preceding simple repetitive finger movements were recorded in 11 normal volunteers. By modeling the recorded data with multiple equivalent dipoles we found that bilateral sources in the motor cortex were the best fitting hypothesis for the early BP. The activity of the source contralateral to the moving finger was increased(More)
Transcranial magnetic stimulation (TMS) of the human brain is mainly used for the diagnosis of diseases with disturbed central motor conduction. Recent studies revealed controversial results concerning the possibility of a TMS-induced specific activation of epileptogenic foci in patients with localization-related epilepsies, which would make TMS an(More)
Patients with idiopathic and symptomatic restless legs syndrome (RLS) suffer from "dyskinesia while awake" or "daytime myoclonus" when at rest preceded by sensory symptoms. In order to characterise the RLS either as reflex movement or as voluntary movement we measured movement-related cortical potentials in 5 idiopathic and 8 uraemic RLS patients. Movements(More)
Mirror movements (MMs) are involuntary movements executed on one side of the body during voluntary movements of the contralateral homologous body parts which may abnormally persist into adulthood. In 6 subjects affected by persistent MM with autosomal dominant inheritance, movement-related cortical potentials (MRCPs) during self-paced, voluntary extensions(More)
Area V4 has been located in man in the region of the fusiform gyrus on the inferior surface of the occipital lobe. Using multiple dipole source analysis on multichannel EEG recordings of visual evoked potentials to coloured 'Mondrian' stimuli in man, we have confirmed that activity is consistently seen in this area regardless of the retinal area stimulated(More)
OBJECTIVES Resistance to activated protein C (APC) is the most frequent cause of thrombophilia and a well known risk factor for deep and cerebral vein thrombosis. Its causative role in ischaemic stroke is still a matter of debate. We undertook this study to determine the prevalence of APC-resistance in a cohort of consecutive patients with acute ischaemic(More)
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose(More)