Hans Hildebrand

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BACKGROUND Numerous studies have reported on the association between coeliac disease and the otherwise uncommon enteropathy-type T cell lymphoma (ETTL). A systematic risk assessment of more prevalent lymphoma entities, such as B cell and non-intestinal lymphomas, in coeliac disease has not been performed. AIMS In light of the increasing number of patients(More)
BACKGROUND An increased incidence of paediatric Crohn's disease was reported recently by our group. AIMS To assess the incidence and characteristics of inflammatory bowel disease (IBD) in northern Stockholm between 1990 and 2001. METHODS All records of individuals 0-15 years of age with suspected IBD in the population based catchment area of 180000(More)
Around 1 in 4 patients with inflammatory bowel disease (IBD) present in childhood, the majority around the time of their pubertal growth spurt. This presents challenges over and above those of managing IBD in adults as this period is a time of dramatic psychological and physical transition for a child. Growth and nutrition are key priorities in the(More)
OBJECTIVES A sharp increase in paediatric (younger than 16 years) inflammatory bowel disease (IBD) incidence was observed in northern Stockholm County, Sweden, in 1990-2001. The increasing incidence was primarily explained by a rising incidence of Crohn disease (CD). Here, we present an update on the trends in incidence of paediatric IBD, 2002-2007. (More)
OBJECTIVE Coeliac disease is associated with an increased risk of malignant lymphomas. We investigated the importance of coeliac disease characteristics and diet compliance for risk of lymphoma. METHODS In a nested case-control design, we identified 59 patients with lymphoma and 137 matched controls from a population-based cohort of 11,650 inpatients with(More)
OBJECTIVE An inappropriate immune response to normal bowel flora is implicated in the etiology of Crohn's disease. Tolerance to bowel flora develops in infancy, so factors disrupting normal patterns of bowel colonization may increase the risk of Crohn's disease. The aim of this study was to test the hypothesis that antibiotic therapy between birth and age 5(More)
BACKGROUND Intranasal budesonide is an efficacious treatment for perennial allergic rhinitis. Long-term effects on safety, particularly in children, need further investigation. OBJECTIVE To investigate the long-term safety of intranasal budesonide in children. METHODS In an open trial, 78 children (5-15 years) with perennial rhinitis were treated with(More)
BACKGROUND Crohn's disease (CD) could involve an inappropriate immune response against normal bowel flora. Disrupted or atypical patterns of microbial bowel colonization may impair development of homeostasis between gut flora and the immune system. Perinatal microbial exposures may be particularly important in stimulating intestinal immune recognition. As(More)
Methods for the determination of pancreatic lipase in small intestinal content have been re-evaluated in the light of the presence of co-lipase therein. A method is described for the determination of co-lipase in intestinal content based on its property to reactivate bile-salt-inhibited lipase. Figures are given for lipase and co-lipase activities in(More)
The purpose of this study is to assess the sensitivity and specificity of magnetic resonance imaging (MRI) in the diagnosis of anterolateral impingement of the ankle and to assess the most helpful sequence in making the diagnosis. Twenty-four patients who had undergone ankle arthroscopy were chosen. Twelve patients had arthroscopically documented(More)