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  • Steffen Weik, Torsten Luksch, +6 authors Jörg Rademann
  • Chemistry, Medicine
  • ChemMedChem
  • 2006 (First Published: 10 April 2006)
  • A synthetic concept is presented that allows the construction of peptide isostere libraries through polymer-supported C-acylation reactions. A phosphorane linker reagent is used as a carbanionContinue Reading
    The substitution of an active-site aspartic acid residue by asparagine in the lysosomal protease cathepsin D (CTSD) results in a loss of enzyme activity and severe cerebrocortical atrophy in a novelContinue Reading