Hans-Gerhard Burgert

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We have recently shown that the accumulation of diverse viral and cellular membrane proteins in the ER activates the higher eukaryotic transcription factor NF-kappaB. This defined a novel ER-nuclear signal transduction pathway, which is distinct from the previously described unfolded protein response (UPR). The well characterized UPR pathway is activated by(More)
The adenovirus type 2 encoded protein E3/19K binds to human histocompatibility class I antigens (HLA). This association occurs both in adenovirus-infected cells and in cells that have been transfected with the gene encoding the E3/19K protein. The formation of the HLA-E3/19K complex prevents the HLA antigens from being correctly processed by inhibiting(More)
We have genetically engineered three alleles of the K locus of the major histocompatibility complex (MHC) of the mouse. These novel hybrid H-2K genes were introduced into mouse 1T 22-6 cells (H-2q), and their products were shown to be expressed on the cell surface. The hybrid H-2 K antigens were examined for their ability to function as restricting elements(More)
We have previously expressed in transgenic mice a chimeric H-2Kd/Kk protein called C31, which contains the extracellular alpha 1 domain of Kd, whereas the rest of the molecule is of Kk origin. This molecule functions as a restriction element for alloreactive and influenza A-specific cytotoxic T lymphocytes (CTL) but is only weakly expressed at the cell(More)
Clonal deletion plays a major part in the maintenance of natural self-tolerance in both normal and transgenic mice. Self antigens that are expressed in the thymus result in the physical elimination of autoreactive thymocytes at a particular stage in their development. For example, the majority V beta 6- and V beta 8.1-bearing T cells that recognize the(More)
Progenitor T cells undergo a complex differentiation process in the thymus, in which the T cell repertoire in the periphery is created. After the initial rearrangement ofTCR genes, at least two selection steps are thought to influence the further development. Both involve interactions ofthe TCR and MHC antigens (1-3). During the first process T cells(More)
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