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Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
We describe a new generation of heterocyclic nonpeptide matrix metalloproteinase (MMP) inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. A screening effort was utilized to identify some chiralExpand
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Isoshamixanthone: a new pyrano xanthone from endophytic Aspergillus sp. ASCLA and absolute configuration of epiisoshamixanthone
Abstract Isoshamixanthone (1), a new stereoisomeric pyrano xanthone together with the previously known fungal metabolites, epiisoshamixanthone (2), sterigmatocystin (3), arugosin C (4),Expand
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Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermentedExpand
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(THF)3LiCl as a ligand for low-coordinate Fe(II): crystal structure of [(Me3Si)2N]2Fe(-Cl)Li(THF)3.
The pale-green, air-sensitive complex [(Me3Si)2N]2Fe(μ-Cl)Li(THF)3 was synthesized serendipitously by the reaction of iron(II) chloride in THF with 1 equiv of KN(SiMe3)2 and subsequent addition ofExpand
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Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.
The crystal structure and unambiguous absolute configuration of meleagrin (1) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases of single crystal X-rayExpand
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Coumamarin: a first coumarinyl calcium complex isolated from nature
The first calcium complex from nature, Coumamarin (1), 7-hydroxy-3-methoxy-2-oxo-2H-chromene-6-carboxylate Ca(II) complex, was isolated from Aspergillus sydowii ASTI, together with diorcinol (2),Expand
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The structure of chloromethyl thiocyanate, CH2ClSCN, in gas and crystalline phases.
The structural and conformational properties of chloromethyl thiocyanate, CH2ClSCN, were studied in the solid phase and in the gas phase using in situ low-temperature single-crystal X-ray diffractionExpand
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Carbene complexes of phosphorus(V) fluorides substituted with perfluoroalkyl-groups synthesized by oxidative addition. Cleavage of the complexes reveals a new synthetic protocol for ionic liquids.
The crystal structures of the previously reported 2,2-difluoro-1,3-dimethylimidazolidine and its acyclic analog were determined by in situ crystallization. Both liquid fluorinating agents haveExpand
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Reactivity of the inversely polarized phosphaalkenes RP=C(NMe2)2 (R = tBu, Me3Si, H) towards arylcarbene complexes [(CO)5M=C(oEt)Ar] (Ar= Ph, M = Cr, W; Ar = 2-MeC6H4, 2-MeOC6H4, M = W).
The reaction of the arylated Fischer carbene complexes [(CO)5M=C(OEt)Ar] (Ar=Ph; M = Cr, W; 2-MeC6H4; 2-MeOC6H; M = W) with the phosphaalkenes RP=C(NMe2), (R=tBu, SiMe3) afforded the novelExpand
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