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MHC ligands and peptide motifs: first listing
The purpose of this article is to provide a compendium of major histocompatibility complex (MHC) peptide motifs and MHC ligands known to date, together with a discussion of the methods used to gainExpand
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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, althoughExpand
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The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway*
The heat shock protein Gp96 has been shown to induce specific immune responses. On one hand, this phenomenon is based on the specific interaction with CD91 that mediates endocytosis and results inExpand
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Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens
The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cellExpand
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Two new proteases in the MHC class I processing pathway
The proteasome generates exact major histocompatibility complex (MHC) class I ligands as well as NH2-terminal-extended precursor peptides. The proteases responsible for the final NH2-terminalExpand
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Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.
NKG2D ligands (NKG2DLs) mark malignant cells for recognition by natural killer (NK) cells and cytotoxic T lymphocytes via the activating immunoreceptor NKG2D. This led to the hypothesis that NKG2DLsExpand
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Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy.
We adoptively transferred donor-derived cytomegalovirus (CMV)-specific T-cell lines into 8 stem cell transplant recipients lacking CMV-specific T-cell proliferation. All patients, of whom one wasExpand
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Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
MHC–peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenicExpand
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Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
VIRUS-infected cells can be eliminated by cytotoxic T lymphocytes (CTL), which recognize virus-derived peptides bound to major histocompatibility complex (MHC) class I molecules on the cellExpand
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MHC Ligands and Peptide Motifs
1. History and Overview -- 2. The MHC Genes -- 3. The Structure -- 4. The Function -- 5. Recognition by Immune Cells -- Appendix A: Useful Internet Addresses -- Appendix B: Computer Programs --Expand
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