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Although expression of the IGF-II has been demonstrated within the central nervous system (CNS), past studies have failed to reveal its precise roles or responses subsequent to a traumatic injury. To demonstrate that IGF-II, IGFBP, and IGF receptor (-R) expression alters in response to a penetrating CNS injury, we used the techniques of ribonuclease(More)
The current integrated developments in network and computing give rise to a technical infrastructure for the information society which one may variously circumscribe by terms such as ubiquitous computing, telepresence and the network as one giant global database. The paper applies to the network the metaphor of global database, and subsumes the aspects of(More)
A precise role for insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGF-receptors (IGF-Rs) in damaged central nervous system (CNS) tissue has not been elucidated, although their expression in the ischemic brain has been demonstrated. However, little is known of IGF responses after CNS trauma. In this study, we have used ribonuclease(More)
Object-oriented database systems are emerging as the “next generation” DBMSs for advanced applications, e.g., VLSI design, mechanical CAD/CAM, software engineering, etc. However, a close analysis indicates that the requirements imposed by these application domains cannot be met by an object-oriented model that relies purely onpassive objects. In this work(More)
Objects are collected into an object base because of a presumed need for cooperation among them. In classical object bases the cooperation is based on synchronous, preplanned message exchange. Many of the modern application scenarios such as industrial and oce automation with their high volume of concurrent, interleaved, and iterative actions defy(More)