Hans-Dirk Duengen

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IMPORTANCE Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression. OBJECTIVE To assess the efficacy and safety of long-term aldosterone receptor blockade in heart failure with preserved ejection fraction. The primary(More)
OBJECTIVES We sought to determine whether structured exercise training (ET) improves maximal exercise capacity, left ventricular diastolic function, and quality of life (QoL) in patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND Nearly one-half of patients with heart failure experience HFpEF, but effective therapeutic(More)
AIMS Heart failure with normal ejection fraction (HFnEF) is an important clinical entity that remains incompletely understood. The novel biomarker growth differentiation factor 15 (GDF-15) is elevated in systolic heart failure (HFrEF) and is predictive of an adverse outcome. We investigated the clinical relevance of GDF-15 plasma levels in HFnEF. METHODS(More)
Comorbidities negatively affect prognosis more strongly in heart failure with preserved (HFpEF) than with reduced (HFrEF) ejection fraction. Their comparative impact on physical impairment in HFpEF and HFrEF has not been evaluated so far. The frequency of 12 comorbidities and their impact on NYHA class and SF-36 physical functioning score (SF-36 PF) were(More)
Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have(More)
AIMS Cardiac remodelling might be an important mechanism for aldosterone-mediated cardiovascular (CV) morbidity and mortality. Previous studies relating aldosterone to left ventricular (LV) structure however revealed conflicting results. METHODS AND RESULTS We aimed to evaluate the relationship of serum aldosterone concentration (SAC) and(More)
AIMS In this randomized, double-blind clinical study, we investigated the relationship between autoantibodies against cardiac troponin I (cTnI) and disease severity in elderly congestive heart failure (CHF) patients before and after titration of beta-blocker therapy. METHODS AND RESULTS Anti-cTnI, cTnI, and N-terminal pro-brain natriuretic peptide(More)
OBJECTIVE General self-efficacy has been found to be an influential variable related to the adaptation to stress and chronic illness, with the General Self-Efficacy (GSE) Scale by Jerusalem and Schwarzer being a reliable and valid instrument to assess this disposition. The aim of this study was to construct and test a short form of this scale to allow for a(More)
ZIEL: N-Terminales Pro-B-Typ Natriuretisches Peptid (NT-proBNP) ist ein starker Prädiktor für Sterblichkeit bei Patienten mit akuter und chronischer Herzinsuffizienz bedingt durch eine ischämische Herzerkrankung. Hingegen ist die prognostische Aussagekraft bei Patienten mit nicht-ischämischer Herzerkrankung weit weniger etabliert. Wir haben daher den(More)
Systolic chronic heart failure (CHF) is currently one of the most prevalent cardiac diseases. The present analysis sought to estimate the 1-year disease-related resource use and associated management costs of patients with CHF. A total of 2,710 individuals with systolic CHF [mean age 62.9 years ± 13.6, 25.2% female, New York Heart Association (NYHA) I–IV](More)