Hans-Dieter Carl

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OBJECTIVE To investigate the effect of chondromodulin 1 on the phenotype of osteochondral progenitor cells in cartilage repair tissue. METHODS Self-complementary adeno-associated virus (AAV) vectors carrying chondromodulin 1 complementary DNA (AAV-Chm-1) were applied to cartilage lesions in the knee joints of miniature pigs that were treated by the(More)
OBJECTIVE To identify factors that are responsible for the phenotypic differences between transient chondrocytes within human osteophytes prone to endochondral ossification and permanent chondrocytes within articular cartilage persisting for decades. METHODS Differential gene expression of chondrocytes from human osteophytes or from articular cartilage(More)
Limited weight bearing of the lower extremity is a commonly applied procedure in orthopaedic rehabilitation after reconstructive forefoot surgery, trauma surgery and joint replacement. The most frequent limitations are given as percentage of body weight (BW) and represent 10 or 50% BW. The extent of foot loading under these graduations of partial weight(More)
BACKGROUND After reconstructive forefoot surgery, patients require complete or partial forefoot relief, which can be obtained with a variety of shoe designs. The aim of this study was to evaluate the effectiveness of two different types of forefoot-relief shoes frequently used after surgery, especially their safety against unintentional forefoot load. (More)
BACKGROUND There is a lack of data on the functional effect of open hip synovectomy in a large number of patients with juvenile rheumatoid arthritis evaluated with a validated assessment tool. METHODS Between 1985 and 1997, sixty-seven open hip-joint synovectomies were carried out in fifty-six patients with juvenile rheumatoid arthritis. Fifty-five hips(More)
For primary uncemented hip arthroplasty, various stem designs are available. The cementless CLS® Spotorno stem has been used for more than 20 years. We re-evaluated a group of patients previously examined for a 10-year follow-up to assess the clinical and radiological stem performance in the long run. Between 1987 and 1988, a consecutive series of 107(More)
OBJECTIVE To investigate the use of a physical strain trainer for the monitoring of partial weight bearing. DESIGN Case series with healthy volunteers. SETTING Orthopedic clinic. PARTICIPANTS Healthy volunteers (N=10) with no history of foot complaints. INTERVENTIONS Volunteers were taught to limit weight bearing to 10% body weight (BW) and 50% BW,(More)
PURPOSE To investigate the long-term outcome of combined arthroscopic and radiation synovectomy of the knee joint in early cases of rheumatoid arthritis (RA) with regard to knee function and the need for surgical re-interventions. METHODS Between 1993 and 1997, a consecutive series of 38 RA patients with therapy-refractory synovitis of the knee joint and(More)
For uncemented hip arthroplasty, various cup designs are available. The threaded Weill acetabular component (Weill cup; Zimmer, Winterthur, Switzerland) has been used for more than 20 years, with poor results of the smooth threaded design. Our study was intended to assess the 17-year outcome of the rough-blasted option of the threaded Weill cup. Between(More)
OBJECTIVE The present study measured the difference in peak plantar pressure between running shoes and soccer shoes in male soccer professionals [mean (SD): age, 23 (4) years; height, 184 (7) cm; weight, 81 (6) kg]. DESIGN Case series. SETTING Institutional study. PARTICIPANTS A total of 17 elite male soccer professionals [mean (SD): age, 23 (4)(More)