Hans B. Sieburg

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Hematopoietic stem cells (HSCs) display extensive heterogeneity in their behavior even when isolated as phenotypically homogeneous populations. It is not clear whether this heterogeneity reflects inherently diverse subsets of HSCs or a homogeneous population of HSCs diversified by their response to different external stimuli. To address this, we analyzed 97(More)
The natural and medical sciences have strongly benefitted from technological advances that help to create and store more raw information than can be effectively processed. In particular, this rapid growth has created a strong need for a flexible and far-reaching approach to cross-database simulation. The paper uses a highly simplified example, called the(More)
We describe a discrete dynamical systems approach to exploring the hypothesis-trees associated with wetlab experiments. On-going applications of the method to experimental research using a genetically engineered mouse animal model with severe combined immune deficiency (SCID) in the area of HIV infection are outlined as an example. In conclusion, we survey(More)
Discerning significant relationships in small data sets remains challenging. We introduce here the Hamming distance matrix and show that it is a quantitative classifier of similarities among short time-series. Its elements are derived by computing a modified form of the Hamming distance of pairs of symbol sequences obtained from the original data sets. The(More)
The life-long supply of blood cells depends on the long-term function of hematopoietic stem cells (HSCs). HSCs are functionally defined by their multi-potency and self-renewal capacity. Because of their self-renewal capacity, HSCs were thought to have indefinite lifespans. However, there is increasing evidence that genetically identical HSCs differ in(More)
BACKGROUND Post-translational modifications (PTMs) impact on the stability, cellular location, and function of a protein thereby achieving a greater functional diversity of the proteome. To fully appreciate how PTMs modulate signaling networks, proteome-wide studies are necessary. However, the evaluation of PTMs on a proteome-wide scale has proven to be(More)
This pap er describes a development system for designing, implementing, and executing biologically motivated cellular automaton simulations. A new object-based programming language that is fund ament al to th e system is discussed in detai l. Use of th e language is illust rated in simple applicat ions. 1. I ntroduction T he simulation and modeling approach(More)
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