Learn More
768 pages. The book presents all the necessary theory for the successful practice of automatic process control. The significance of the theory is explained at all times. Both introductory. Significant advances have been made in the field since the previous classic texts were written. This text brings the available knowledge up to date. * Enables the reader(More)
Hematopoietic stem cells (HSCs) display extensive heterogeneity in their behavior even when isolated as phenotypically homogeneous populations. It is not clear whether this heterogeneity reflects inherently diverse subsets of HSCs or a homogeneous population of HSCs diversified by their response to different external stimuli. To address this, we analyzed 97(More)
For decades, hematopoietic stem cells (HSCs) were thought to be a homogeneous population of cells with flexible behavior. Now a new picture has emerged: The HSC compartment consists of several subpopulations of HSCs each with distinct, preprogrammed differentiation and proliferation behaviors. These programs are epigenetically fixed and are stably(More)
Myeloperoxidase (MPO) is a myeloid-specific enzyme that generates hypochlorous acid and other reactive oxygen species. MPO is present at high levels in circulating neutrophils and monocytes but is not detectable in microglia, brain-specific macrophages, in normal brain tissue. However, an earlier study indicated that MPO is present in macrophage-microglia(More)
The natural and medical sciences have strongly benefitted from technological advances that help to create and store more raw information than can be effectively processed. In particular, this rapid growth has created a strong need for a flexible and far-reaching approach to cross-database simulation. The paper uses a highly simplified example, called the(More)
Previously we reported that the size of the stem cell compartment (measured as LTC-IC) is 11-fold greater in DBA/2 than in C57BL/6 mice, and we identified genes that regulate the size of the stem cell pool. To determine whether stem cell intrinsic or extrinsic events account for these differences, we created chimeras by aggregating morulae from the strains(More)
We describe a discrete dynamical systems approach to exploring the hypothesis-trees associated with wetlab experiments. On-going applications of the method to experimental research using a genetically engineered mouse animal model with severe combined immune deficiency (SCID) in the area of HIV infection are outlined as an example. In conclusion, we survey(More)
Discerning significant relationships in small data sets remains challenging. We introduce here the Hamming distance matrix and show that it is a quantitative classifier of similarities among short time-series. Its elements are derived by computing a modified form of the Hamming distance of pairs of symbol sequences obtained from the original data sets. The(More)
Figure 6: Virtual reality rehabilitation exercise using a peg board. [Burdea et al., 1997] c The MIT Press. Reprinted by permission 7 Figure 4: Endoscopic Sinus Surgery simulator [Wiet et al., 1997]. tube-like organs. The procedure requires skill and a learning curve in BLOCKINuencing the time a surgeon spends in the OR. Boston Dynamics Inc. has developed a(More)