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A variable aspect of an application domain is called a hot spot [6, 8]. Different applications from a domain differ from one another with regard to some (at least one) of the hot spots. An application supplies, for each hot spot, one (or several) of the different possible alternatives of the A framework [5] is a generic application that allows the creation(More)
Leptin decreases food intake and increases energy expenditure in rodents by inhibiting neurones in the hypothalamic arcuate nucleus. The growth hormone secretagogue (GHS) ghrelin is known to stimulate food intake and to be the endogenous ligand for the GHS-receptor, which is strongly expressed in the arcuate nucleus, like the leptin receptor (Ob-R). In this(More)
Relaxin, a peptide hormone secreted by the corpus luteum during pregnancy, exerts actions on reproductive tissues such as the pubic symphysis, uterus, and cervix. It may also influence body fluid balance by actions on the brain to stimulate thirst and vasopressin secretion. We mapped the sites in the brain that are activated by i.v. infusion of a dipsogenic(More)
State-of-the-art Web applications include both navigational elements and business processes, but most Web application design methods treat business processes as just another kind of navigation. The authors' extensions to the object-oriented hypermedia design method (OOHDM) aim to remedy this situation. Rather than using navigation to emulate business(More)
Dichotomizing sensory axons have been demonstrated in a number of species and are of significance in understanding the possible mechanisms underlying referred pain. The present study reviews work employing fluorescent dyes as tracers to demonstrate afferent dichotomization in the peripheral nervous system. Dichotomization between the intercostal and(More)
1. Extracellular recordings were obtained from 94 warm-sensitive, 6 cold-sensitive and 117 temperature-insensitive neurones in slices of the hypothalamic medial preoptic area of rats, to determine the effect of the GABAA agonist muscimol, the GABAA antagonist bicuculline, the GABAB agonist baclofen and the GABAB antagonist phaclofen on tonic activity and(More)
Chick ciliary ganglion neurons have nicotinic acetylcholine receptors (AChRs) that mediate synaptic transmission through the ganglion. A cAMP-dependent process has previously been shown to enhance the ACh response of the neurons 2- to 3-fold without requiring the synthesis of new receptors. We show here that the receptors can be phosphorylated in situ by a(More)
In this paper we discuss several issues related to the introduction of business processes in the life cycle of Web based E-commerce applications. We first argue that business processes have been so far neglected by modeling and design methodologies treating them as by-products of conceptual and navigational design artifacts, and as a consequence introducing(More)
The class and interaction structure of object-oriented designs may become fairly complex, and consequently difficult to develop and understand. Design patterns allow to govern this complexity. This paper presents the design process of a domain-specific black-box framework for the control of automated manufacturing systems. The design is performed as a(More)
We have developed an injection technique which simplifies the use of fluorescent tracers in investigating the projections of peripheral nerves both in rats and pigeons, and avoids the difficulties experienced with the cut nerve technique. The tracers are injected into the peripheral nerve and transported to cell bodies in the dorsal root ganglia (DRG). By a(More)