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Excessive dietary P intake alone can be deleterious to bone through increased parathyroid hormone (PTH) secretion, but adverse effects on bone increase when dietary Ca intake is low. In many countries, P intake is abundant, whereas Ca intake fails to meet recommendations; an optimal dietary Ca:P ratio is therefore difficult to achieve. Our objective was to(More)
For the correct development of the central nervous system, the balance between self-renewing and differentiating divisions of the neuronal progenitors must be tightly regulated. To maintain their self-renewing identity, the progenitors need to retain both apical and basal interfaces. However, the identities of fate-determining signals which cells receive(More)
BACKGROUND We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. This was tested in a mouse model. METHODS Balb/c mice were epicutaneously sensitized with ovalbumin and challenged with 10 intragastric ovalbumin administrations every second day. Smooth muscle contractility of isolated circular jejunal sections was studied in(More)
This study focuses on the early temperamental (TTQ = toddler temperament questionnaire), behavioral (IBR = infant behavior record), and cognitive precursors of impaired language functioning in preschool-age pre-terms infants. The study group consisted of 63 pre-term infants with a mean birth weight of 1246 +/- 437 g born in 1989-1991 in the University(More)
BACKGROUND The plant stanol ester margarine Benecol is a functional food that has been shown to lower effectively serum total and LDL-cholesterol. The purpose of this post-marketing study is to characterize users of plant stanol ester margarine with and without cardiovascular disease. METHODS A cohort of plant stanol ester margarine users was established(More)
During retinal development, six different neuronal classes and one glial cell type arise in a conserved, temporal sequence from multipotent, cycling retinal progenitor cells (RPCs). Developing tissues, such as the retina, are exquisitely sensitive to timing of Notch signaling. Interestingly, removal of Notch1 during retinal development resulted in cell(More)
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