Hannan Humayun Khan

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BACKGROUND Extensive lines of radiofrequency (RF) lesions through infarct (MI) can ablate multiple and unstable ventricular tachycardias (VTs). Methods for guiding ablation that minimize unnecessary RF applications are needed. This study assesses the feasibility of guiding RF line placement by mapping to identify a reentry circuit isthmus. METHODS AND(More)
BACKGROUND Ventricular tachycardia reentry circuits in chronic infarct scars can contain slow conduction zones, which are difficult to distinguish from bystander areas adjacent to the circuit during catheter mapping. This study developed criteria for identifying reentry circuit sites using computer simulations. These criteria then were tested during(More)
Ventricular tachycardia late after myocardial infarction is usually due to reentry in the infarct region. These reentry circuits can be large, complex and difficult to define, impeding study in the electrophysiology laboratory and making catheter ablation difficult. Pacing through the electrodes of the mapping catheter provides a new approach to mapping.(More)
Study was designed to elucidate the mechanism of hypotensive effect of garlic extract in dogs. The antagonists for common endogenous hypotensive substances (histamine, Acetylcholine, 5 Hydroxy Tryptamine Kinins and prostaglandins) were tried to confirm or exclude the possibility that garlic extract either acts like or causes release of any one of these(More)
Myocardial infarct scars giving rise to reentrant ventricular tachycardia can contain "bystander" areas of abnormal electrical activity that are difficult to distinguish from reentry circuit sites. Pacing to entrain ventricular tachycardia with analysis of electrograms at the pacing site is useful to identify reentry circuit sites but assumes that(More)
Teeth once designated obsolete for rehabilitation and deemed for extraction should be re-evaluated for salvaging two thirds or even one-third component of the individual teeth. In our part of the continent, financial restraints can effect the orthodox procedures of root amputation if the final restoration is not provided at an earlier date. This case report(More)
The effects of a number of potential antagonists of dantrolene sodium have been studied on twitches of the isolated hemidiaphragm preparation of the rat stimulated directly at a frequency of 0-1 Hz, after complete neuromuscular block produced by tubocurarine or erabutoxin a. The substances selected as possible dantrolene antagonists were uranyl ions,(More)
The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1.5-2 kg. Pretreatment of animals with aspirin (50 mg/kg i/v) suppressed all arrhythmias during ischaemia. Low dose of aspirin(More)