Hannah Sexmith

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This article is available online at http://www.jlr.org Epidemiological studies show a strong inverse relationship between circulating levels of HDL cholesterol (HDL-C) and coronary artery disease (CAD) in patients with high, normal, or low LDL cholesterol (LDL-C) levels ( 1, 2 ). However, HDL-C-raising therapies using cholesteryl ester transfer protein(More)
Background/Objective:Youth with obesity have an altered high-density lipoprotein (HDL) subspecies profile characterized by depletion of large apoE-rich HDL particles and an enrichment of small HDL particles. The goal of this study was to test the hypothesis that this atherogenic HDL profile is reversible and that HDL function would improve with metabolic(More)
We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with T2D. Four groups of adolescents were recruited: 1) lean insulin-sensitive (L-IS), normal BMI and no insulin resistance; 2) lean insulin-resistant (L-IR), normal BMI but insulin resistance (fasting(More)
HDL cholesterol (HDL-C) efflux function may be a more robust biomarker of coronary artery disease risk than HDL-C. To study HDL function, apoB-containing lipoproteins are precipitated from serum. Whether apoB precipitation affects HDL subspecies composition and function has not been thoroughly investigated. We studied the effects of four common apoB(More)
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