Hannah En Hui Yuan
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Specific incorporation of cyclophilin A into HIV-1 virions
LITTLE is known about host factors necessary for retroviral virion assembly or uncoating. We have previously shown that the principal structural protein of the human immunodeficiency virus HIV-1, the… Expand
Positive control of yeast meiotic genes by the negative regulator UME6.
The yeast meiotic activator IME1 stimulates transcription of many early meiotic genes. These genes share a 5' sequence called URS1. URS1 sites function as repression sites in cells that lack IME1; we… Expand
Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1.
Many yeast genes that are essential for meiosis are expressed only in meiotic cells. Known regulators of early meiotic genes include IME1, which is required for their expression, and SIN3 and UME6,… Expand
Specificity and sequence requirements for interactions between various retroviral Gag proteins.
- E. K. Franke, H. Yuan, K. L. Bossolt, S. Goff, J. Luban
- Biology, Medicine
- Journal of virology
- 1 August 1994
We previously established a genetic assay for retroviral Gag polyprotein multimerization (J. Luban, K. B. Alin, K. L. Bossolt, T. Humaran, and S. P. Goff, J. Virol. 66:5157-5160, 1992). Here we use… Expand
Genetic evidence for transcriptional activation by the yeast IME1 gene product.
IME1 is required in yeast for meiosis and for expression of IME2 and other early meiotic genes. IME1 is a 360-amino acid polypeptide with central and C-terminal tyrosine-rich regions. We report here… Expand
Genetic Characterization ofvif, vpr,andvpuSequences from Long-Term Survivors of Human Immunodeficiency Virus Type 1 Infection
Abstract The identification of HIV-1-infected individuals who remain asymptomatic despite prolonged infection presents a unique opportunity to understand virologic and host factors involved in the… Expand
Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.
The cellular peptidyl-prolyl isomerase cyclophilin A (CyPA) is incorporated into human immunodeficiency virus type 1 (HIV-1) virions via direct contacts with the HIV-1 Gag polyprotein. Disruption of… Expand