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MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
This work identifies MafG as an FXR target gene and shows that hepatic MAFG overexpression represses genes of the bile Acid synthetic pathway and modifies the biliary bile acid composition. Expand
The Nuclear Receptor FXR Uncouples the Actions of miR-33 From SREBP-2
It is demonstrated that the activation of FXR uncouples the expression of nuclear SREBP-2 and miR-33, and the regulation of their respective target genes, and it is concluded that the FXR agonist-dependent increase in miR -33 requires transcription of the Srebp-2 gene. Expand
Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates
The results of the screen reveal novel expression-based lineage patterns within the brain, the imaginal disc epithelia, and the hematopoietic lymph gland, which are compiled into the G-TRACE Expression Database (GED), an online resource for use by the Drosophila research community. Expand
Abstract 636: The Nuclear Receptor FXR Uncouples the Actions of Srebp2 and MiR-33
This work identifies miR-33 as a direct target gene of the bile acid nuclear receptor FXR, and suggests that FXR induces two independent microRNAs that function together to repress ABCA1 and reduce HDL levels. Expand
Abstract 49: The Transcriptional Repressor MafG Regulates Cholesterol Catabolism
An FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes is identified and a molecular mechanism for the complex feedback regulation of bile acids synthesis controlled by FXR is identified. Expand