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The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor clinical outcome in childhood neuroblastoma,… Expand
Members of the MYC family are the most frequently deregulated oncogenes in human cancer and are often correlated with aggressive disease and/or poorly differentiated tumors. Since patients with… Expand
Significance Angiogenesis, the development of blood vessels within a solid tumor, is not only essential for primary tumor growth but also vital for tumor invasion and metastasis. The TP73 gene, a… Expand
Summary In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients. Identifying the metabolic adaptations crucial for… Expand
Expression of MYC is deregulated in a wide range of human cancers, and is often associated with aggressive disease and poorly differentiated tumor cells. Identification of compounds with selectivity… Expand
MYCN is a member of the MYC family of proto-oncogenes, encoding transcription factors (cMYC, MYCN and L-MYC) that play crucial roles for normal cellular functions and during development. However, the… Expand