Hanna Tuhkanen

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BACKGROUND Transcription factor Snail1 has a central role in induction of epithelial-mesenchymal transition (EMT). The aim of the present study was to elucidate the expression of Snail1 protein during epithelial ovarian tumourigenesis and to study the association of Snail1 expression with clinicopathological factors and prognosis. METHODS Epithelial and(More)
BACKGROUND Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT. METHODS We used immunohistochemistry to investigate the expression of zeb1, twist and snai1 in tumor and stromal compartments by in a(More)
BACKGROUND Epithelial-mesenchymal transition (EMT) is a crucial process in tumorigenesis since tumor cells attain fibroblast-like features enabling them to invade to surrounding tissue. Two transcription factors, TWIST and SNAI1, are fundamental in regulating EMT. METHODS Immunohistochemistry was used to study the expression of TWIST and SNAI1 in 109(More)
Nine patients receiving a low dose (25 mg) and ten receiving a standard dose (150 mg) of depot haloperidol every four weeks were assessed every three months for two years. Patients also received targeted oral neuroleptics as needed. No significant between-group differences were found in clinical outcome as measured by number of hospital admissions, days(More)
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