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In previous studies human mesenchymal stromal cells (MSCs) maintained the “stemness” of human hematopoietic progenitor cells (HPCs) through direct cell–cell contact in two-dimensional co-culture systems. We establish a three-dimensional (3D) co-culture system based on a custom-made chip, the 3D-KITChip, as an in vitro model system of the human hematopoietic(More)
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