Hanna Braun

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Myelodysplastic syndromes (MDS) are triggered by an aberrant hematopoietic stem cell (HSC). It is, however, unclear how this clone interferes with physiologic blood formation. In this study, we followed the hypothesis that the MDS clone impinges on feedback signals for self-renewal and differentiation and thereby suppresses normal hematopoiesis. Based on(More)
BACKGROUND Depressive episodes in schizophrenia constitute a major clinical problem, and treatment success is often limited by treatment-emergent side effects. Agomelatine, an agonist at melatonergic MT1/MT2 receptors and 5-HT2C receptor antagonist, is a new antidepressant with a novel mode of action which constitutes a potential therapeutic option for(More)
Three children are described who between 5 and 7 years of age developed behaviour disorders and comprehension deficit for acoustic language. All had associated spike-and-wave discharges in the EEG. Clinical seizures occurred after the onset of aphasia and were easily controlled by anticonvulsant treatment. The aphasia disappeared but without clear-cut(More)
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