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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response.

• Michael B Oldstone, Michael Nerenberg, Peter J. Southern, J. Price, Hanna A Lewicki
• Cell
• 1991

We investigated the potential association between viruses and insulin-dependent (type 1) diabetes (IDDM) by developing a transgenic mouse model. By inserting into these mice a unique viral protein… (More)

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

• Persephone Borrow, Hanna A Lewicki, +8 authors George M. Shaw
• Nature Medicine
• 1997

The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus… (More)

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.

• Persephone Borrow, Hanna A Lewicki, Beatrice H. Hahn, G. M. Shaw, Michael B Oldstone
• Journal of virology
• 1994

Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary… (More)

Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells

• Noemí Sevilla, Stefan Kunz, +6 authors Michael B Oldstone
• The Journal of experimental medicine
• 2000

Among cells of the immune system, CD11c(+) and DEC-205(+) splenic dendritic cells primarily express the cellular receptor (alpha-dystroglycan [alpha-DG]) for lymphocytic choriomeningitis virus… (More)

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis.

• Simone Visosky Ward, Cyril X George, +6 authors Michael B Oldstone
• Proceedings of the National Academy of Sciences…
• 2011

Measles virus (MV), a member of the family Paramyxoviridae and an exclusively human pathogen, is among the most infectious viruses. A progressive fatal neurodegenerative complication, subacute… (More)

Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics.

• Sara C Smelt, Persephone Borrow, +5 authors Michael B Oldstone
• Journal of virology
• 2001

alpha-Dystroglycan (alpha-DG) was recently identified as a receptor for lymphocytic choriomeningitis virus (LCMV) and several other arenaviruses, including Lassa fever virus (W. Cao, M. D. Henry, P.… (More)

Monoclonal antibodies to lymphocytic choriomeningitis and pichinde viruses: generation, characterization, and cross-reactivity with other arenaviruses.

• Michael J. Buchmeier, Hanna A Lewicki, Owale Tomori, Michael B Oldstone
• Virology
• 1981

Mass spectrometry reveals specific and global molecular transformations during viral infection.

• Eden P. Go, William R. Wikoff, +13 authors Gary Siuzdak
• Journal of proteome research
• 2006

Mass spectrometry analysis was used to target three different aspects of the viral infection process: the expression kinetics of viral proteins, changes in the expression levels of cellular proteins,… (More)

CTL escape viral variants. I. Generation and molecular characterization.

• Hanna A Lewicki, Antoinette Tishon, +6 authors Michael B Oldstone
• Virology
• 1995

Cytotoxic T lymphocytes (CTL) play a pivotal role in preventing persistent viral infections and aborting acute infections. H-2Db-restricted CTL optimally recognize a specific peptide of 9 to 11 amino… (More)

V and C proteins of measles virus function as virulence factors in vivo.

• Jackie Patterson, D. Thomas, Hanna A Lewicki, Martin Billeter, Michael B Oldstone
• Virology
• 2000

The measles virus (MV) P gene encodes three proteins: the P protein and two nonstructural proteins, C and V. Because the functions of both the C and V protein are unknown, we used MV C (C-) and V… (More)

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