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Calcium imaging is a versatile experimental approach capable of resolving single neurons with single-cell spatial resolution in the brain. Electrophysiological recordings provide high temporal, but limited spatial resolution, because of the geometrical inaccessibility of the brain. An approach that integrates the advantages of both techniques could provide(More)
Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular,(More)
Recent research in brain-machine interfaces and devices to treat neurological disease indicate that important network activity exists at temporal and spatial scales beyond the resolution of existing implantable devices. High density, active electrode arrays hold great promise in enabling high-resolution interface with the brain to access and influence this(More)
In one-third of epilepsy patients, antiepileptic drugs do not effectively control seizures, leaving resective surgery as the primary treatment option. In the absence of discrete focal lesions, long-term outcome after surgery is modest and often associated with side effects. In many cases, surgery cannot be performed due to the lack of a discrete region(More)
Organic transistor technology holds great promise for creating a conformal, human-safe electronic neural interface. These interfaces must amplify the low, microvolt-range brain signals so they can be utilized in analog and digital applications. Brain signals from sensors must be relayed to the transistor's gate through the dielectric and semiconductor(More)
Hepatic gluconeogenic substrates (alanine, lactate, and glycerol) transport have been studied in liver plasma membrane vesicles from rats bearing the ascitic tumor Yoshida AH-130 hepatoma. Hepatic alanine uptake was increased in membrane vesicles from tumor-bearing animals as compared with those isolated from non-tumor-bearing controls. Although no changes(More)
  • W Bredt, H Bink
  • 1977
Two liquid media and two agar media were compared for their sensitivity in the isolation of Ureaplasma urealyticum. 22 of the 144 urine specimens examined were positive. The U9-medium with low serum content showed a higher isolation rate and earlier results than a medium with 20% serum (Table 1). However some cultures grew sometimes better in the serum rich(More)
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