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We describe a Bayesian method based on Markov chain simulation to study the phylogenetic relationship in a group of DNA sequences. Under simple models of mutational events, our method produces a Markov chain whose stationary distribution is the conditional distribution of the phylogeny given the observed sequences. Our algorithm strikes a reasonable balance(More)
Many margin-based binary classification techniques such as support vector machine (SVM) andψ-learning deliver high performance. An earlier article proposed a new multicategory ψ-learning methodology that shows great promise in generalization ability. However, ψ-learning is computationally difficult because it requires handling a nonconvex minimization(More)
BACKGROUND The frailty syndrome is as a well-established condition of risk for disability. Aim of the study is to explore whether a physical activity (PA) intervention can reduce prevalence and severity of frailty in a community-dwelling elders at risk of disability. METHODS Exploratory analyses from the Lifestyle Interventions and Independence for Elders(More)
The Pl(A2) polymorphism of the glycoprotein IIIa subunit of the fibrinogen receptor (GPIIb-IIIa) has been reported by some studies to be associated with an increased risk of coronary thrombosis. Following the first paper on the subject in 1996, a large number of studies have investigated the relationship between this polymorphism and coronary thrombosis,(More)
We consider situations in Bayesian analysis where we have a family of priors νh on the parameter θ, where h varies continuously over a space H, and we deal with two related problems. The first involves sensitivity analysis and is stated as follows. Suppose we fix a function f of θ. How do we efficiently estimate the posterior expectation of f(θ)(More)
Consider the model in which the data consist of possibly censored lifetimes, and one puts a mixture of Dirichlet process priors on the common survival distribution. The exact computation of the posterior distribution of the survival function is in general impossible to obtain. This paper develops and compares the performance of several simulation(More)
A reduced risk of primary malignant adult brain tumors is observed among people reporting asthma, hay fever, and other allergic conditions; however, findings may be attributed to prediagnostic effects of tumors or recall bias. To determine whether asthma and allergic condition polymorphisms are inversely related to glioblastoma multiforme (GBM) risk, we(More)