OBJECTIVE
To determine which clinical, laboratory, and imaging features most accurately distinguished gout from non-gout.
METHODS
We performed a cross-sectional study of consecutive rheumatology… (More)
Rheumatoid arthritis (RA) is characterized by fibroblast-like synoviocyte (FLS) hyperplasia, which is partly ascribable to decreased apoptosis. In this study, we show that adrenomedullin (ADM), an… (More)
Basic calcium phosphate (BCP) crystals are associated with severe osteoarthritis and acute periarticular inflammation. Three main forms of BCP crystals have been identified from pathological tissues:… (More)
OBJECTIVES
To compare the sensitivity and specificity of different classification criteria for gout in early and established disease.
METHODS
This was a cross-sectional study of consecutive… (More)
Basic calcium phosphate and pyrophosphate calcium crystals are the 2 main calcium-containing crystals that can deposit in all skeletal tissues. These calcium crystals give rise to numerous… (More)
INTRODUCTION
Calcium-containing (CaC) crystals, including basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP), are associated with destructive forms of osteoarthritis (OA). We… (More)
OBJECTIVES
To assess diagnoses and management of acute and chronic gout in primary care and rheumatology settings relative to 2006 European League Against Rheumatism (EULAR) gout recommendations.… (More)
BACKGROUND
Osteoarthritis (OA) is characterised by cartilage degradation and bone lesions. Subchondral bone may be involved in the pathogenesis of cartilage matrix breakdown.
OBJECTIVE
To assess… (More)
PURPOSE OF REVIEW
Calcium pyrophosphate dihydrate and basic calcium phosphate crystals are the two most common calcium-containing crystals involved in rheumatic diseases. Recent literature concerning… (More)
INTRODUCTION
Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of… (More)