Hang Fai Kwok

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A central role for venom in predation by Varanus komodoensis (Komodo Dragon) and the extinct giant Varanus (Megalania) priscus.

Bryan G Fry, Stephen Wroe, +25 authors Janette Ann Norman
Proceedings of the National Academy of Sciences…
2009

The predatory ecology of Varanus komodoensis (Komodo Dragon) has been a subject of long-standing interest and considerable conjecture. Here, we investigate the roles and potential interplay between… (More)

Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattle.

Clare Whelan, Eduard Shuralev, +17 authors John Clarke
Clinical and vaccine immunology : CVI
2008

Efforts to develop a better diagnostic assay for bovine tuberculosis have shown that the sensitivity and specificity of an assay can be improved by the use of two or more antigens. As reported here,… (More)

Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma).

Bryan G Fry, Kim Roelants, +8 authors Janette Ann Norman
Molecular biology and evolution
2010

The origin and evolution of venom proteins in helodermatid lizards were investigated by multidisciplinary techniques. Our analyses elucidated novel toxin types resultant from three unique… (More)

Functional and structural diversification of the Anguimorpha lizard venom system.

Bryan G Fry, Kelly Winter, +19 authors Wayne C. Hodgson
Molecular & cellular proteomics : MCP
2010

Venom has only been recently discovered to be a basal trait of the Anguimorpha lizards. Consequently, very little is known about the timings of toxin recruitment events, venom protein molecular… (More)

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

Kenneth A. Botkjaer, Hang Fai Kwok, +7 authors Gillian Murphy
Oncotarget
2016

The membrane-associated matrix metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous tissues. It is substantially… (More)

Recent advances in the field of anti-cancer immunotherapy.

BACKGROUND The main goal of anti-cancer therapy is to specifically inhibit the malignant activity of cancer cells, while leaving healthy cells unaffected. As such, for every proposed therapy, it is… (More)

Helokinestatin: a new bradykinin B2 receptor antagonist decapeptide from lizard venom.

Hang Fai Kwok, Tianbao Chen, Martin O'rourke, Craig Ivanyi, David Graham Hirst, Chris Shaw
Peptides
2008

Synthetic bradykinin antagonist peptides/peptoids have been powerful tools for delineating the roles of kinins in both normal physiology and in pathological states. Here, we report the identification… (More)

Osteopontin -- a promising biomarker for cancer therapy

Ran Wei, Janet Pik Ching Wong, Hang Fai Kwok
Journal of Cancer
2017

Osteopontin (OPN), a multifunctional protein, has emerged as a potentially valuable biomarker for diagnosing and treating cancers. Recent research focuses on its involvement in tumor biology… (More)

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.

Takehiko Takayanagi, Steven J. Forrester, +9 authors Satoru Eguchi
Hypertension
2016

Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances cardiovascular… (More)

Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy.

Hang Fai Kwok, Kenneth A. Botkjaer, Christopher J Tape, Yanchao Huang, John McCafferty, Gillian Murphy
Protein engineering, design & selection : PEDS
2014

We previously showed that a human anti-TACE antibody, D1(A12), is a potent inhibitor of TNF-α converting enzyme (TACE) ectodomain proteolysis and has pharmacokinetic properties suitable for studies… (More)

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