Few technologies are more widespread in modern biological laboratories than imaging. Recent advances in optical technologies and instrumentation are providing hitherto unimagined capabilities. Almost all these advances have required the development of software to enable the acquisition, management, analysis and visualization of the imaging data. We review… (More)
Understanding the structure of single neurons is critical for understanding how they function within neural circuits. BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recognized need for openness and standardization to provide a community resource for automated… (More)
The next grand challenges for society and science are in the brain sciences. A collection of 60+ scientists from around the world, together with 10+ observers from national, private, and foundations, spent two days together discussing the top challenges that we could solve as a global community in the next decade. We eventually settled on three challenges,… (More)
The last 20 years have seen great advances in optical imaging with the introduction of the ability to monitor biological phenomena with unprecedented resolution, specificity, dimensionality, complexity and scale, all while maintaining viability and biological relevance. These imaging modalities, which are increasingly multiparametric, rely heavily on… (More)
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