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PURPOSE To determine if changing from 1.5T to 3T breast magnetic resonance imaging (MRI) is associated with a change in BI-RADS categories, positive predictive value of biopsy recommendation, or cancer detection rates in high-risk screening breast MRI. MATERIALS AND METHODS Institutional Review Board (IRB) approval was obtained for this Health Insurance(More)
PURPOSE Physiotherapists frequently prescribe home exercise programmes for individuals with Parkinson's disease (PD) and Huntington's disease (HD); however, little is known about clients' perceptions of such programmes and any barriers that may affect participation and compliance. METHOD A qualitative design was used to capture the attitudes and(More)
AIMS With the increase in the number of systematic reviews available, a logical next step to provide decision makers in healthcare with the evidence they require has been the conduct of reviews of existing systematic reviews. Syntheses of existing systematic reviews are referred to by many different names, one of which is an umbrella review. An umbrella(More)
Reviews of primary research are becoming more common as evidence-based practice gains recognition as the benchmark for care, and the number of, and access to, primary research sources has grown. One of the newer review types is the 'scoping review'. In general, scoping reviews are commonly used for 'reconnaissance' - to clarify working definitions and(More)
Pulmonary embolism (PE) is the leading cause of maternal mortality in the developed world. Mortality from PE in pregnancy might be related to challenges in targeting the right population for prevention, ensuring that diagnosis is suspected and adequately investigated, and initiating timely and best possible treatment of this disease. Pregnancy is an example(More)
OBJECTIVE The aim of this study was to explore feasibility, safety and outcome of an exercise intervention in people with Huntington's disease. DESIGN A randomized controlled pilot trial. SETTING A home-based exercise programme. SUBJECTS A total of 25 subjects with early to mid-stage Huntington's disease. INTERVENTION Subjects were randomly(More)
BACKGROUND Clinical intervention trials in people with Huntington disease (HD) have been limited by a lack of reliable and appropriate outcome measures. OBJECTIVE The purpose of this study was to determine the reliability and minimal detectable change (MDC) of various outcome measures that are potentially suitable for evaluating physical functioning in(More)
PURPOSE To investigate the capacity of a single triaxial accelerometer sensor in detecting gait and balance impairments in pre-manifest and manifest Huntington's disease (HD) subjects. METHODS Fourteen manifest HD (MHD) (age: 51.83±14.8), ten pre-manifest HD (PHD) (age: 44.8±11.7) and ten healthy subjects (HLY) (age: 56.4±10.9) were recruited. The sensor(More)
BACKGROUND Individualized exercise instruction on a regular basis may be desirable for people with Huntington disease (HD). Sustained interventions, however, may not be the most feasible for lifelong disease management. It is critical, therefore, for physical therapists to find ways to facilitate engagement in independent exercise programs. The capabilities(More)
BACKGROUND AND PURPOSE The clinical symptoms of Huntington disease (HD) include progressive movement disorders, cognitive deficits, and behavioral changes, all of which affect an individual's ability to participate in activities of daily living. To date, very few quantitative or qualitative studies have been conducted to guide physical therapists working(More)