Hanaa M. Ibrahim

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OBJECTIVES The aim of the present work was to reveal the mechanisms of melatonin treatment on ethanol-induced gastric mucosal lesions in rats, including its role in the induction of ghrelin biosynthesis. METHODS Sixty male Wistar rats were divided into 3 groups (20 in each group): a) control group, b) ulcer group (100% ethanol was given intragastrically(More)
Childhood sarcoidosis is a rare chronic multisystem granulomatous disease with variable presentations. It has two distinct forms: the juvenile form and the early onset form. Early onset sarcoidosis is caused by nucleotide-binding oligomerization domain 2 (NOD2) mutation and is closely associated with dysfunction of the innate immunity. Symptomatic(More)
OBJECTIVES The involvement of the opioid system in energy balance has been known for several decades but many questions remain unanswered. Therefore, this study was designed to investigate the effect of the non-selective opioid receptor antagonist (LY255582) on high fat diet (HFD)-induced obesity. METHODS Twenty-four adult male albino rats were divided(More)
OBJECTIVE We aimed to investigate the effect of ghrelin antagonist (D-Lys3) GHRP-6 on the treatment of ovariectomy-induced obesity as compared to hormone replacement therapy with estradiol. METHODS Twenty eight rats were divided into four groups: control sham operated (C), ovariectomized non-treated (OVX), ovariectomized+estradiol-treated (OVX+E) groups,(More)
Chlorpyrifos (CPF) is a chlorinated organophosphate insecticide that is used widely in the world and Egypt. The aim of present work was to study the possible protective role of Propolis on thyroid gland of male rats after chronic exposure of chlorpyrifos. For this purpose, Fifty adult male albino rats were randomized into 5 groups: I, II (Control), III(More)
Aim of work: The role of pancreatic polypeptide family including Neuropeptide Y (NPY), and Peptide Tyrosine Tyrosine (PYY) in obesity development and its metabolic changes is controversial due to multiple receptor involvement. Therefore, this study was designed to investigate the effect of a potent Y2 receptor agonist; Peptide Tyrosine Tyrosine (PYY3-36) on(More)
INTRODUCTION Colorectal cancer (CRC) incidence is increasing globally. It is ranked as the second most common cancer in women and the third most in men. Angiogenesis plays a significant role in the development and spread of colorectal cancer. Angiogenesis has been proposed as a prognostic marker in a variety of human neoplasms. In this regard, markers of(More)
Cypermethrin and permethrin are widely used in the agriculture in many countries. Continuous low level exposure of human to such chemicals may increase the susceptibility to various diseases due to the suppression of immune system. Therefore, the aim of the present study is to evaluate the toxicity of these pesticides at immunological, hematological and(More)
The present study was conducted to investigate effect of pentoxifylline (PTX) on acute liver injury caused by galactosamine (D-Gal) in rats and the underlying mechanism involved in this setting. Moreover, we attempted to compare its effect to the well-established hepatoprotective agent, silymarin (SYM). The rats were randomly assigned 5 groups, control,(More)
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