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Given the vicissitudes of percutaneous coronary intervention (PCI) technology, epidemiology, and mode of practice, the aim of this study was to define contemporary outcome predictors in a very large consecutive patient cohort. Data from 11,441 consecutive patients who underwent PCI at a tertiary medical center from April 2004 to September 2013 are(More)
OBJECTIVE Transcatheter aortic valve implantation (TAVI) is occasionally associated with stroke and silent cerebral ischemia, which may affect cognitive and functional performance. The aim of this study was to evaluate the changes in cognitive performance and functional status following TAVI. METHODS We performed a comprehensive prospective functional,(More)
Accurate risk stratification has an important role in the management of patients with acute coronary syndromes. Even in patients with ST-elevation acute myocardial infarction (STEMI), for whom early therapeutic options are well defined, risk stratification has an impact on early and late therapeutic decision making. We aimed to compare the prognostic value(More)
OBJECTIVES To ascertain the long-term safety, efficacy, and pattern of use of drug-eluting stents (DES) in routine clinical practice. METHODS We analyzed a registry of 6,583 consecutive patients undergoing percutaneous coronary intervention (PCI), of whom 2,633 were treated using DES (DES group) and 3,950 were treated using bare-metal stents (BMS group).(More)
OBJECTIVES We aim to explore the clinical outcome of drug-eluting stents (DES) versus bare-metal stents (BMS) implantation in diabetics versus nondiabetic patients. BACKGROUND Diabetic patients sustain worse long-term clinical outcomes after percutaneous coronary interventions (PCI) when compared with nondiabetics. The use of DES decreases the rate of(More)
BACKGROUND Manual coronary thrombus aspiration was associated with improved outcomes of ST-elevation myocardial infarction (STEMI) patients. We aimed to evaluate the outcome of aspiration in a "real-world" setting of primary percutaneous coronary intervention (PPCI). METHODS AND MATERIALS We analyzed the outcome of STEMI patients who underwent PPCI(More)
OBJECTIVES We investigated the impact of primary coronary angioplasty performed during night and compared to the impact of that performed during day-time on outcomes of patients with acute ST elevation anterior wall myocardial infarction (AMI). METHODS We prospectively followed 273 consecutive patients of whom 160 (58.6%) were treated during day time(More)
Aortic valve stenosis is associated with severe morbidity and death within several years of symptom onset, and its accepted treatment is surgical aortic valve replacement. However, many affected patients are not referred for surgery because of old age and significant comorbidities. In recent years, an alternative treatment approach has been developed,(More)
Fractional flow reserve (FFR) is considered the gold standard for invasive assessment of functional, significant coronary stenosis. Nevertheless, its application and outcome in daily practice is rarely reported. We investigated whether decisions in clinical practice adhered to FFR-generated recommendations and whether FFR influenced cardiovascular outcomes.(More)
Pretreatment with clopidogrel before elective primary percutaneous coronary intervention (PCI) has been shown to reduce ischemic complications. There are limited data about the value of clopidogrel pretreatment in the setting of PCI for ST-elevation myocardial infarction (STEMI). We aimed to examine the effect of clopidogrel preloading on angiographic and(More)