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Internet coordinate systems embed Round-Trip-Times (RTTs) between Internet nodes into some geometric space so that unmeasured RTTs can be estimated using distance computation in that space. If accurate, such techniques would allow us to predict Internet RTTs without extensive measurements. The published techniques appear to work very well when accuracy is(More)
Round trip times (RTTs) play an important role in Internet measurements. In this paper, we explore some of the ways in which routing policies impact RTTs. In particular, we investigate how routing policies for both intra-and inter-domain routing can naturally give rise to violations of the triangle inequality with respect to RTTs. Triangle Inequality(More)
—This paper presents a new technique for noise cancellation and signal separation, which is capable of identifying channel dynamics in real time, removing noise effectively, and separating source signals by reconfiguring signal transmission channels during different phases of source signals. This method is motivated by extracting authentic heart and lung(More)
Born-Oppenheimer ab initio QM/MM molecular dynamics simulation with umbrella sampling is a state-of-the-art approach to calculate free energy profiles of chemical reactions in complex systems. To further improve its computational efficiency, a mass-scaling method with the increased time step in MD simulations has been explored and tested. It is found that(More)
We demonstrated the surface functionalization of a highly three-dimensional, superhydrophilic wicking substrate using light to immobilize functional biomolecules for sensor or microarray applications. We showed here that the three-dimensional substrate was compatible with photo-attachment and the performance of functionalization was greatly improved due to(More)
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