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Masqueraders who impersonate other users pose serious threat to computer security. Unfortunately, firewalls or misuse-based intrusion detection systems are generally ineffective in detecting masquerades. Although anomaly detection techniques have long been considered as an effective approach to complement misuse detection techniques, they are not widely(More)
Since computed tomography (CT) was developed and its resolution, sensitivity, and scan speed rapidly improved, the use of CT in the diagnosis of hepatic disease has been evaluated by various investigators. [1] In particular, liver-specific X-ray CT imaging has attracted much attention in cancer diagnosis and cancer treatment because liver metastases are a(More)
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. This study investigated the effects of systemic transplantation of human ASCs (hASCs) on bone repair. We found that hASCs secrete various bone cell-activating factors, including hepatocyte growth factor(More)
Regulation of the formation and function of bone-resorbing osteoclasts (OCs) is a key to understanding the pathogenesis of skeletal disorders. Gene-targeting studies have shown that the RANK signaling pathway plays a critical role in OC differentiation and function. Although pharmaceutical blockade of RANK may be a viable strategy for preventing bone(More)
This paper presents the stiffness analysis and design of a 3-DOF parallel robot with one constraining leg, which takes into account of elastic deformations of joints and links. The parallel manipulator in this study is made up of three SPS (Spherical-Prismatic -Spherical) legs and one UP (Universal-Prismatic) leg at the center. The role of the UP leg(More)
Schizophrenia is one of the most devastating of all mental illnesses, and has dimensional characteristics that include both positive and negative symptoms. One problem reported in schizophrenia patients is that they tend to show deficits in face emotion processing, on which negative symptoms are thought to have stronger influence. In this study, four(More)
Frequency of attacks on Web services and resulting damage continue to grow as Web services become popular. Unfortunately, existing signature-based intrusion detection techniques are inadequate in providing reasonable degree of Web security. Web attacks are diverse in nature, and typical Web architecture consists of complex and hierarchically organized(More)
RASSF2 belongs to the Ras-association domain family (RASSF) of proteins, which may be involved in the Hippo signalling pathway. However, the role of RASSF2 in vivo is unknown. Here, we show that Rassf2 knockout mice manifest a multisystemic phenotype including haematopoietic anomalies and defects in bone remodelling. Bone marrow (BM) transplantation showed(More)
PURPOSE Coexistence of different classes of beta-lactamases in a single bacterial isolate may pose diagnostic and therapeutic challenges. We investigated a spread of Klebsiella pneumoniae isolates co-producing an AmpC beta-lactamase and an extended-spectrum beta-lactamase (ESBL) in a university hospital. MATERIALS AND METHODS Over a three-month period, a(More)
PURPOSE Luminal-type breast cancer has a good prognosis compared to other types, such as human epidermal growth factor receptor 2 and triple negative types. Luminal-type breast cancer is classified into luminal A and B, according to the proliferation index. We investigated the clinicopathological factors that affect the prognosis of the luminal-type(More)