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We used CDK4/hTERT-immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common lung cancer oncogenic changes (p53, KRAS, and MYC) and followed the stepwise transformation of HBECs to full malignancy. This model showed that: (i) the combination of five genetic(More)
We propose a novel capacity model for complex networks against cascading failure. In this model, vertices with both higher loads and larger degrees should be paid more extra capacities, i.e. the allocation of extra capacity on vertex i will be proportional to k γ i , where ki is the degree of vertex i and γ > 0 is a free parameter. We have applied this(More)
Single trial electroencephalogram (EEG) classification is essential in developing brain-computer interfaces (BCIs). However, popular classification algorithms, e.g., common spatial patterns (CSP), usually highly depend on the prior neurophysiologic knowledge for noise removing, although this knowledge is not always known in practical applications. In this(More)
The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of(More)
Caveolin-1 is one of the major constituents of caveolae. Both Cav-1 and PrP are plasma membrane proteins, which show active capacities for molecular interactions with many other proteins or agents, including themselves. Using yeast two-hybrid system and immunoprecipitation, we reconfirmed the molecular interaction between human Cav-1 and PrP. With(More)
BACKGROUND The aim of this study was to examine the differences in diet, physical activity, and weight status among children living in rural and urban America and to study the roles of obesity-related behaviors in residence-based differences in childhood obesity. METHODS We performed cross-sectional analysis of the 1999-2006 National Health and Nutrition(More)