Learn More
We used CDK4/hTERT-immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common lung cancer oncogenic changes (p53, KRAS, and MYC) and followed the stepwise transformation of HBECs to full malignancy. This model showed that: (i) the combination of five genetic(More)
$ (( $ 2 ' ' $$( ' 3 ) $ ' ' ' $ 3 () + 4 $ ( ' 2 ( 5 6( ' ( ' 789 ' ( ' 7:9) ' 6( ' ( ' 6 ; < 3 4 $ (( $ 7#9) " ' $$( 6( ' ( ' 4 ( ' = >1?) 1' 4 ' + ) #) ' $ ' ( ' ' @6 ' ' ' ' * $ ) 1' $ $ $ ( ' ' $ =; <? $ $ 3 ' 6( ) ' ' $ $ ( ) , $ (( ' ( $ ' $ ( ( ' ) ' * ' ( ' ( 6 @ ( ' @ ) ' ( @ = ? 7# 9 @ ' $ ' ' ( ' ) ' * @ =,? 7A # #:9 '( $ 4 $ ' ( ( ( $ ' $( ) '(More)
Tumor cells can engage in a process called collective invasion, in which cohesive groups of cells invade through interstitial tissue. Here, we identified an epigenetically distinct subpopulation of breast tumor cells that have an enhanced capacity to collectively invade. Analysis of spheroid invasion in an organotypic culture system revealed that these(More)
An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of(More)
BACKGROUND The aim of this study was to examine the differences in diet, physical activity, and weight status among children living in rural and urban America and to study the roles of obesity-related behaviors in residence-based differences in childhood obesity. METHODS We performed cross-sectional analysis of the 1999-2006 National Health and Nutrition(More)
Two new gallotannins, pistafolins A (1) and B (2), were isolated from the leaf extract of Pistacia weinmannifolia. Their structures were determined by spectral methods. Four known gallotannins (3-6), seven known flavonoid glycosides (7-13), along with 1-O-beta-D-(6'-O-galloyl)-glucopyranosyl-3-methoxy-5-hydroxybenzen e (14), gallic acid (15), methyl gallate(More)