• Citations Per Year
Learn More
Using reputation system to help determine trustworthiness of online entities is a widely adopted method in the current web environment. Reputation bootstrapping, known as determining a default reputation value for a newcomer, is an important issue which currently is short of a proper solution. In this paper, we introduce a new concept, marginal reputation(More)
BACKGROUND AND PURPOSE Mitogen-activated protein (MAP) and tyrosine kinases play an important role in regulating smooth muscle contraction of the gastrointestinal (GI) tract. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. Thus, the role of MAP and tyrosine kinases on the pacemaker potentials of colonic ICCs(More)
Trust and reputation systems are widely adopted to help online consumers choose trustworthy suppliers. One problem is that consumers are only attracted by high-reputation holders, which disadvantages the newcomers entering the market, even they provide better goods or services. In this paper, we propose an online supplier selection model in which online(More)
Background/Aims We investigated the role of representative endoplasmic reticulum proteins, stromal interaction molecule 1 (STIM1), and store-operated calcium entry-associated regulatory factor (SARAF) in pacemaker activity in cultured interstitial cells of Cajal (ICCs) isolated from mouse small intestine. Methods The whole-cell patch clamp technique(More)
EP receptor activation by PGE2 regulates gastrointestinal motility by modulating smooth muscle contractility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate smooth muscle activity. We aimed to determine effects of the EP3 receptor agonist sulprostone on pacemaker potentials in colonic ICCs. We performed a whole cell patch clamp,(More)
Trust and reputation systems are widely adopted in the e-commerce environment to help buyers choose trustworthy sellers. It is a normal thought that the higher the reputation is, the more trustworthy its holder should be. However, our research discloses that under certain circumstances, a high-reputation seller has greater intention to cheat, which means(More)
To investigate the role of ATP-sensitive K+(KATP) channels on pacemaker activity in interstitial cells of Cajal (ICC), whole-cell patch clamping, RT-PCR, and intracellular Ca2+([Ca2+]i) imaging were performed in cultured colonic ICC. Pinacidil (a K+ channel opener) hyperpolarized the membrane and inhibited the generation of pacemaker potential, and this(More)
The pharmacokinetics of fudosteine in healthy Chinese volunteers was investigated for the first time after single- and multiple-dose administration. Five male and five female volunteers were enrolled in this study. Each subject received 400 mg fudosteine capsules (the therapeutic dose) on day 1 after overnight fasting for the single-dose study and three(More)