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This multicenter, first-in-human study evaluated the safety, tolerability, and pharmacokinetic and pharmacodynamic properties of the anti-CS1 monoclonal antibody elotuzumab. A standard 3 + 3 design was used to determine maximum tolerated dose; dose-limiting toxicities were assessed during cycle 1. Thirty-five patients with relapsed/refractory multiple(More)
Although several adhesion molecules expressed on leukocytes (beta1 and beta2 integrins, platelet endothelial cell adhesion molecule 1 [PECAM-1], and CD47) and on endothelium (intercellular adhesion molecule 1, PECAM-1) have been implicated in leukocyte transendothelial migration, less is known about the role of endothelial lateral junctions during this(More)
Regular free-weight exercise helps to strengthen the body's natural movements and stabilize muscles that are important to strength, balance, and posture of human beings. Prior works have exploited wearable sensors or RF signal changes (e.g., WiFi and Blue tooth) for activity sensing, recognition and countingetc.. However, none of them have incorporate three(More)
Leukocyte adhesion to vascular endothelium under flow involves an adhesion cascade consisting of multiple receptor pairs that may function in an overlapping fashion. P-selectin glycoprotein ligand-1 (PSGL-1) and L-selectin have been implicated in neutrophil adhesion to P- and E-selectin under flow conditions. To study, in isolation, the interaction of(More)
By using the concept of gauge function, a pseudodistance function is defined for quantifying the clearance or the penetration depth of two convex point sets, depending on whether they separate or intersect. The linear programming formulations (for convex polyhedra) and the nonlinear constrained optimization formulations (for general convex objects) are(More)
Different from online shopping, in-store shopping has few ways to collect the customer behaviors before purchase. In this paper, we present the design and implementation of an on-site Customer Behavior IDentification system based on passive RFID tags, named CBID. By collecting and analyzing wireless signal features, CBID can detect and track tag movements(More)
L-selectin mediates leukocyte rolling on vascular endothelium during inflammation. Although vascular endothelium can be activated with inflammatory cytokines to express functional L-selectin ligands, these ligands have not been well characterized. In this study, fucosyltransferase VII cDNA (Fuc-TVII) transfection of the EA.hy926 human vascular endothelial(More)
Nanos is a necessary factor in the differentiation and migration of primordial germ cells. It is closely associated with the development of genitalia in a wide range of species. We questioned whether Nanos was involved in the reproductive organ development of Schistosoma japonicum. Firstly, by in situ hybridization, S. japonicum Nanos1 (SjNanos1) gene(More)