Hamish Duncan

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OBJECTIVE To assess the safety and efficacy of minocycline in the treatment of rheumatoid arthritis. DESIGN A double-blind, randomized, multicenter, 48-week trial of oral minocycline (200 mg/d) or placebo. SETTING 6 clinical centers in the United States. PATIENTS 219 adults with active rheumatoid arthritis who had previous limited treatment with(More)
The junction between cellular pannus and cartilage/bone was identified grossly on rheumatoid metacarpal heads. Its topography was displayed by scanning electron microscopy using macerated samples. A uniform pattern of resorption bays, typical of osteoclastic activity, was seen spreading over the surfaces of both calcified cartilage and subchondral bone. The(More)
Hypothermic machine perfusion (HMP) has a potential to relieve the current donor liver crisis by providing an improved and extended preservation method. This study examined the effect of HMP on hepatocellular functions, using a prototype liver transporter capable of preserving livers for 24 hours. Livers obtained from adult farm pigs (28 to 32 kg body(More)