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A new chromanone acid from the stem bark of Calophyllum teysmannii
The preliminary assay results revealed that all the test compounds displayed potent inhibitory activity against HeLa cancer cell line, in particular with compound 1 which exhibited the highest cytotoxic activity comparable to the positive control used, cisplatin. Expand
Antioxidant, Cytotoxic Activities, and Structure–Activity Relationship of Gallic Acid‐based Indole Derivatives
A limited positive structure activity relationship was found between cytotoxic and antioxidant activities and a new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallIC hydrazide and different indole carboxaldehydes. Expand
Synthesis, Characterization, X-ray Crystallography, Acetyl Cholinesterase Inhibition and Antioxidant Activities of Some Novel Ketone Derivatives of Gallic Hydrazide-Derived Schiff Bases
Alzheimer’s disease (AD) is the most common form of dementia among older people and the pathogenesis of this disease is associated with oxidative stress. Acetylcholinesterase inhibitors withExpand
Fabrication of CoTiO3-TiO2 composite films from a heterobimetallic single source precursor for electrochemical sensing of dopamine.
The CoTiO3-TiO2 electrode is a potential candidate for the sensitive and selective detection of dopamine (DA) in thin films characterized by XRD, Raman and X-ray photoelectron spectroscopy, scanning electron microscopy, energy-dispersive X-rays analysis. Expand
3,4,5-Trihydroxy-N′-(1H-indol-3-ylmethylidene)benzohydrazide pentahydrate
The two aromatic parts of the title compound, C16H13N3O4·5H2O, are connected through a conjugated –CH=N–NH–C(O)– fragment, giving an almost planar molecule. The organic molecules and uncoordinatedExpand
Achieving Congruence among Reference Laboratories for Absolute Abundance Measurement of Analytes for Rare Diseases: Psychosine for Diagnosis and Prognosis of Krabbe Disease
Congruence between multiple reference laboratories in the measurement of the absolute concentration of biomarkers in DBS (and by extension other samples) is possible by the use of a common set of DBS calibrators. Expand
Benzyl N′-(1H-indol-3-ylmethylidene)hydrazinecarbodithioate
The C10H8N3S2 portion of the title molecule, C17H15N3S3, is nearly planar (r.m.s. deviation 0.05 Å); this unit and the phenyl ring subtend an angle of 114.5 (2)° at the methylene C atom.
Benzyl N′-(1-methyl-1H-indol-2-ylmethylene)hydrazinecarbodithioate
In the title compound, C18H17N3S2, the dihedral angle between the planes of the aromatic ring systems is 83.63 (16)° and inversion dimers occur, linked by pairs of N—H⋯S hydrogen bonds. Expand
Two new polymorphs of 2,6-diaminopyrimidin-4(3H)-one monohydrate.
The title compound, C(4)H(6)N(4)O·H(2)O, crystallized simultaneously as a triclinic and a monoclinic polymorph from an aqueous solution of 2,4-diaminopyrimidin-6-ol. Previously, an orthorhombicExpand
4-Hydroxy-3-methoxybenzaldehyde–nicotinamide (1/1)
In the title compound, C6H6N2O·C8H8O3, an equimolar co-crystal of nicotinamide and vanillin, the aromatic ring and the amide fragment of the nicotinamide molecule make a dihedral angle of 32.6 (2)°.Expand